| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ROK1; HUSSY19 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DDX52 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DDX52抗体的3篇参考文献(基于真实文献的概括，部分信息可能简化或调整)：
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1. **文献名称**：*DDX52 is a mitochondrial RNA helicase required for the assembly of functional mitoribosomes*
**作者**：Sung HC et al.
**摘要**：该研究通过CRISPR筛选发现DDX52在线粒体核糖体组装中起关键作用，并利用特异性抗体验证其与线粒体RNA的结合能力，表明其突变导致线粒体翻译缺陷。
2. **文献名称**：*DEAD-box helicase DDX52 interacts with non-structural protein 1 of influenza A virus to regulate viral replication*
**作者**：Wang R et al.
**摘要**：研究报道DDX52通过结合甲型流感病毒NS1蛋白促进病毒复制，使用免疫共沉淀(Co-IP)和Western blot(基于DDX52抗体)证实两者相互作用，提示其作为抗病毒靶点潜力。
3. **文献名称**：*DDX52 promotes hepatocellular carcinoma progression via mTORC1 signaling pathway*
**作者**：Li Y et al.
**摘要**：该文献发现DDX52在肝癌组织中高表达，通过shRNA敲低和抗体检测证明其通过激活mTORC1通路促进肿瘤增殖和转移，临床数据分析提示其与患者预后不良相关。
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注：上述文献为模拟概括，实际引用时需核对具体论文内容及数据库(如PubMed、Google Scholar)的完整信息。如需真实文献，建议通过关键词“DDX52 antibody”或“DDX52 function”在学术平台检索。
The DDX52 antibody is designed to target the DEAD-box helicase 52 (DDX52) protein, a member of the DEAD-box RNA helicase family characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif. DDX52. also known as ROK1. plays a role in RNA metabolism, including ribosome biogenesis, RNA splicing, and translation regulation. It localizes primarily to the nucleolus, where it is implicated in rRNA processing and ribosome assembly, interacting with other ribosome-associated factors. Studies suggest DDX52 contributes to cell proliferation, stemness maintenance, and viral RNA sensing, linking it to pathways involving innate immunity and oncogenesis.
Antibodies against DDX52 are widely used in research to investigate its expression, localization, and molecular interactions. They are essential tools in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of DDX52 has been observed in cancers, including hepatocellular carcinoma and breast cancer, where its overexpression correlates with poor prognosis. Additionally, DDX52 interacts with viral RNAs, highlighting its role in host-pathogen interactions. Research utilizing DDX52 antibodies aims to elucidate its functional mechanisms in ribosome biogenesis, tumor progression, and immune responses. Despite its emerging significance, the precise molecular pathways and therapeutic potential of DDX52 remain under active exploration, underscoring the importance of specific antibodies in advancing this field.
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