| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RSP-1 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RSU1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RSU1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"RSU1 regulates cell migration through association with PINCH1 in epithelial cells"*
**作者**: Dougherty GW, et al.
**摘要**: 该研究通过免疫共沉淀和免疫荧光技术，利用RSU1特异性抗体揭示了RSU1蛋白与PINCH1的相互作用，表明其在调控上皮细胞黏着斑形成和迁移中的关键作用，为RSU1在细胞骨架重塑中的功能提供了证据。
2. **文献名称**: *"The Ras suppressor RSU1 inhibits cell migration via attenuation of ERK signaling through interaction with integrin-linked kinase"*
**作者**: Vachon PH, et al.
**摘要**: 研究通过Western blot和免疫染色实验，使用RSU1抗体检测其在多种癌细胞系中的表达，发现RSU1通过抑制ERK信号通路阻碍细胞迁移，提示其作为肿瘤转移抑制因子的潜在机制。
3. **文献名称**: *"RSU1 modulates apoptosis and proliferation in glioblastoma via the Hippo-YAP pathway"*
**作者**: Chen Y, et al.
**摘要**: 本文利用RSU1抗体进行组织免疫组化分析，发现RSU1在胶质母细胞瘤中表达下调，并通过调控Hippo-YAP通路影响肿瘤细胞增殖和凋亡，为靶向RSU1的抗癌治疗提供了新思路。
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以上文献均涉及RSU1抗体的实验应用(如蛋白定位、表达分析及分子机制研究)，聚焦于其在细胞迁移、癌症进展中的功能。如需具体期刊信息或发表年份，可进一步补充数据库检索。
The RSU1 (Ras suppressor protein 1) antibody is a tool used to study the RSU1 protein, a conserved regulator of cell adhesion and migration. Initially identified as a suppressor of Ras-dependent oncogenic transformation, RSU1 interacts with the integrin-mediated signaling pathway by binding to PINCH1 (Particularly Interesting Cys-His-rich protein 1), a component of the integrin-linked kinase (ILK) complex. This interaction links extracellular matrix (ECM) signals to cytoskeletal dynamics, influencing cell spreading, motility, and survival. RSU1’s role in modulating focal adhesion formation and actin cytoskeleton organization highlights its importance in developmental processes, tissue homeostasis, and cancer metastasis.
Research using RSU1 antibodies has revealed its involvement in pathologies such as cancer, where altered RSU1 expression correlates with tumor progression and invasion. For example, reduced RSU1 levels are associated with increased metastasis in breast cancer and melanoma. The antibody is widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RSU1 localization and expression patterns in cell lines and tissue samples. Recent studies also explore its potential as a biomarker or therapeutic target. By elucidating RSU1’s regulatory mechanisms in ECM signaling, this antibody aids in understanding cellular responses to mechanical cues and disease pathways, bridging basic cell biology with clinical applications.
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