| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SLFN5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLFN5抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *SLFN5 expression as a prognostic marker in melanoma*
**作者**: Berger A, et al. (2020)
**摘要**: 该研究通过免疫组化分析发现，SLFN5蛋白在黑色素瘤组织中高表达，并与患者生存率降低相关。研究使用特异性SLFN5抗体证实其可作为潜在的预后标志物。
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2. **文献名称**: *SLFN5 regulates antiviral responses in dendritic cells*
**作者**: Suzuki T, et al. (2018)
**摘要**: 文章探讨了SLFN5在树突状细胞抗病毒反应中的作用，利用SLFN5抗体进行蛋白质定位及表达水平检测，发现其通过干扰素信号通路抑制病毒复制。
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3. **文献名称**: *SLFN5 modulates chemoresistance in ovarian cancer*
**作者**: Zhang L, et al. (2021)
**摘要**: 研究通过Western blot和免疫荧光技术(使用商业化SLFN5抗体)发现，SLFN5高表达与卵巢癌细胞对铂类化疗耐药性相关，机制涉及DNA损伤修复调控。
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如需具体文献，建议通过PubMed或Google Scholar以“SLFN5 antibody”及“SLFN5 function”为关键词检索最新研究。
Schlafen family member 5 (SLFN5) is a protein encoded by the *SLFN5* gene, part of the Schlafen family implicated in cell proliferation, differentiation, and immune regulation. SLFN5. first identified in mice, shares conserved structural features across species, including a Schlafen-specific domain and a divergent C-terminal region. It is expressed in immune cells (e.g., T cells, dendritic cells) and certain cancer cells, where it modulates transcriptional regulation, chromatin remodeling, and antiviral responses. Studies suggest SLFN5 interacts with RNA polymerase II, influencing gene expression by suppressing transcriptional elongation. Its role in immune evasion and tumor progression has drawn interest, as elevated SLFN5 levels correlate with poor prognosis in cancers like melanoma and breast cancer.
SLFN5-specific antibodies are critical tools for studying its expression, localization, and molecular interactions. These antibodies (monoclonal or polyclonal) are typically generated using immunogenic peptide sequences from human or mouse SLFN5. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation. Researchers rely on SLFN5 antibodies to explore its dual roles: as a tumor suppressor via epigenetic silencing of oncogenes or as a pro-tumor factor by dampening antitumor immunity. Challenges include distinguishing SLFN5 from other Schlafen family members (e.g., SLFN11) due to sequence homology, necessitating rigorous specificity validation. Recent studies also investigate SLFN5 phosphorylation and its impact on protein function, further driving demand for high-quality antibodies.
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