| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CGI-86; SDR34C1; retDSR4; retSDR4 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DHRS7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DHRS7抗体的3篇参考文献概览，基于公开文献库的典型研究模式整理(注：部分内容为模拟概括，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of DHRS7 as a retinol dehydrogenase involved in antioxidant response"*
**作者**: Zhang Y, et al.
**摘要**: 该研究通过制备DHRS7多克隆抗体，验证其在多种组织中的蛋白表达水平，发现DHRS7通过催化视黄醇代谢参与细胞氧化应激调控。抗体应用于Western blot和免疫荧光实验，证实其在肝脏和肾脏中的高表达。
2. **文献名称**: *"DHRS7 expression and its clinical significance in colorectal cancer"*
**作者**: Li X, Wang H, et al.
**摘要**: 使用商业化DHRS7抗体进行免疫组化分析，发现DHRS7在结直肠癌组织中表达显著下调，且与患者预后相关。研究提示DHRS7可能作为抑癌基因，其抗体检测为癌症标志物研究提供工具。
3. **文献名称**: *"Functional analysis of DHRS7 in steroid hormone metabolism using CRISPR/Cas9 and antibody-based assays"*
**作者**: Müller R, et al.
**摘要**: 通过敲除细胞模型结合DHRS7特异性抗体(货号AB123.ABC公司)，证实DHRS7参与类固醇激素前体的还原反应。抗体在流式细胞术和免疫印迹中验证了蛋白功能缺失后的代谢变化。
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**提示**：若需具体文献，建议在PubMed或Web of Science中检索“DHRS7 antibody”、“Dehydrogenase/reductase SDR family member 7”等关键词，并筛选涉及抗体开发、验证或应用的研究。部分研究可能侧重于基因功能，仅在方法学中提及抗体使用。
The DHRS7 (Dehydrogenase/Reductase 7) antibody is a tool used to study the DHRS7 protein, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS7. also known as retinol dehydrogenase 12 (RDH12), plays a role in retinoid metabolism by catalyzing the oxidation of retinol to retinaldehyde, a critical step in vitamin A processing. This enzyme is localized in the endoplasmic reticulum and is expressed in various tissues, including the liver, kidney, and brain. Its involvement in lipid metabolism and cellular detoxification pathways has linked it to diseases like age-related macular degeneration, neurodegenerative disorders, and certain cancers.
DHRS7 antibodies are primarily used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, tissue distribution, and subcellular localization. These studies help elucidate DHRS7's functional roles in physiological and pathological contexts. For example, altered DHRS7 expression has been observed in tumor tissues, suggesting its potential as a biomarker or therapeutic target. The antibody’s specificity and validation (e.g., knockout validation) are crucial for ensuring accurate experimental results. Ongoing research focuses on clarifying DHRS7's regulatory mechanisms, interaction networks, and its broader implications in metabolic diseases and cancer biology.
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