| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BDA2; BMP2A; SSFSC; SSFSC1 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BMP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMP2抗体的3篇代表性文献示例(注：文献信息为模拟，供参考格式)：
1. **文献名称**：*"BMP2 Antibody-Based Targeting of Osteogenic Differentiation in Mesenchymal Stem Cells"*
**作者**：Chen et al.
**摘要**：本研究利用BMP2特异性抗体通过Western blot和免疫荧光技术，验证了BMP2在骨髓间充质干细胞成骨分化中的动态表达，并证明其抗体阻断实验可显著抑制成骨标志物(如Runx2)的表达。
2. **文献名称**：*"Immunohistochemical Detection of BMP2 in Breast Cancer Tissues and Its Clinical Implications"*
**作者**：Rosenzweig et al.
**摘要**：通过免疫组化(IHC)分析BMP2在乳腺癌组织中的表达水平，发现BMP2高表达与肿瘤侵袭性正相关，提示其抗体在癌症预后评估中的潜在应用价值。
3. **文献名称**：*"BMP2 Neutralizing Antibody Attenuates Fibrosis in a Murine Model of Myocardial Infarction"*
**作者**：Smith et al.
**摘要**：在小鼠心梗模型中，使用BMP2中和抗体阻断其信号通路，显著减少了心肌纤维化面积，表明靶向BMP2的抗体治疗在抑制病理性纤维化中的潜力。
4. **文献名称**：*"Development of a High-Affinity BMP2 Monoclonal Antibody for Cartilage Regeneration"*
**作者**：Lee et al.
**摘要**：报道了一种新型高亲和力BMP2单克隆抗体的开发，该抗体通过促进BMP2与受体的稳定结合，增强软骨细胞分化和关节修复，为骨关节炎治疗提供新策略。
(注：以上文献为示例，实际引用需查询PubMed、Web of Science等数据库获取真实信息。)
The bone morphogenetic protein 2 (BMP2) antibody is a laboratory tool designed to detect and study BMP2. a secreted signaling molecule belonging to the transforming growth factor-beta (TGF-β) superfamily. BMP2 plays critical roles in embryonic development, skeletal formation, and tissue repair by regulating cell differentiation, proliferation, and apoptosis. It is particularly known for its osteoinductive properties, making it essential in bone and cartilage formation. Dysregulation of BMP2 signaling is linked to pathologies such as cancer, fibrosis, and skeletal disorders.
BMP2 antibodies are widely used in research to investigate the protein's expression, localization, and function. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry to quantify BMP2 levels in tissues or cell cultures. Some antibodies block BMP2-receptor interactions, aiding in mechanistic studies of its signaling pathways. Commercial BMP2 antibodies are typically monoclonal or polyclonal, with validation in specific applications.
In therapeutic contexts, BMP2-targeting antibodies are explored for conditions like heterotopic ossification or tumors driven by BMP2 overexpression. However, their clinical use remains experimental. Researchers must verify antibody specificity due to potential cross-reactivity with homologous BMPs. Overall, BMP2 antibodies are vital for advancing understanding of developmental biology, regenerative medicine, and disease mechanisms.
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