Rabbit Polyclonal TP63 Antibody

The TP63 antibody targets the p63 protein, encoded by the TP63 gene, a member of the p53 tumor suppressor family. Unlike p53. p63 plays a critical role in epithelial development, differentiation, and stem cell maintenance. It exists as multiple isoforms, primarily categorized into transactivation-active (TA) and amino-terminal truncated (ΔN) variants, which exhibit opposing functions: TA isoforms promote differentiation, while ΔN isoforms block apoptosis and sustain progenitor cell proliferation. TP63 antibodies are widely used in research and diagnostics to study p63's expression patterns in normal tissues (e.g., skin, prostate, squamous epithelia) and pathological conditions, particularly cancers. Overexpression of ΔNp63 is linked to squamous cell carcinomas (e.g., head and neck, lung, bladder) and serves as a diagnostic marker. These antibodies are essential tools in immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess protein localization and expression levels. Additionally, they aid in exploring p63's role in regenerative medicine, stem cell biology, and developmental disorders. Researchers must select antibodies validated for specific isoforms and applications, as cross-reactivity with other p53 family members (e.g., p73) can occur. Commercial TP63 antibodies are typically monoclonal or polyclonal, with clone-specific sensitivity and specificity profiles. Proper controls and validation are critical for accurate interpretation in both research and clinical settings.