| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NNP-1; NOP52; RRP1A; D21S2056E |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RRP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RRP1抗体的3篇参考文献的简要总结：
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1. **文献名称**：*"The small subunit processome is required for cell cycle progression at G1 phase"*
**作者**：S. Boulon, et al.
**摘要**：研究揭示了RRP1作为UTP复合物成员，在核糖体小亚基加工中的作用。通过使用RRP1抗体进行免疫荧光和蛋白质互作分析，发现其缺失会阻碍rRNA前体加工，导致细胞周期停滞在G1期，影响增殖。
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2. **文献名称**：*"RRP1 regulates mitotic spindle assembly through interaction with Aurora A kinase"*
**作者**：K. Urano, et al.
**摘要**：该文献利用RRP1抗体进行免疫共沉淀和功能实验，证明RRP1与Aurora A激酶相互作用，调控有丝分裂纺锤体组装。敲低RRP1会导致染色体排列异常，提示其在细胞分裂中的关键作用。
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3. **文献名称**：*"Overexpression of RRP1 correlates with poor prognosis in hepatocellular carcinoma"*
**作者**：X. Zhang, et al.
**摘要**：通过免疫组化(使用RRP1抗体)分析肝癌组织样本，发现RRP1在肿瘤中高表达，且与患者总生存期缩短显著相关，提示其作为潜在预后标志物的价值。
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**注**：以上文献信息为模拟示例，实际引用时请核实具体来源及内容准确性。
The RRP1 (Ribosomal RNA Processing 1) antibody is a tool used to study the RRP1 protein, a key component involved in ribosome biogenesis and RNA processing. RRP1. also known as Exosome Component 3 (EXOSC3), is part of the exosome complex, a multi-subunit machinery critical for processing and degrading various RNA species, including ribosomal RNA (rRNA), small nuclear RNA (snRNA), and messenger RNA (mRNA). It plays a vital role in RNA quality control, maturation, and turnover, ensuring proper cellular function. Dysregulation of RRP1 has been linked to developmental disorders, neurodegenerative diseases, and cancers.
RRP1 antibodies are widely employed in molecular biology research to investigate the protein's expression, localization, and interactions. They are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess RRP1 levels in different tissues or disease models. Such studies help elucidate its role in cellular processes like cell cycle progression, stress responses, and tumorigenesis. Commercial RRP1 antibodies are typically generated in rabbits or mice, targeting specific epitopes of the human RRP1 protein. Validation includes testing for specificity via knockout/knockdown controls. Researchers rely on these antibodies to explore RRP1's functional mechanisms and its potential as a biomarker or therapeutic target in diseases associated with RNA dysregulation.
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