| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FXR2P; FMR1L2 |
| WB Predicted band size | 74 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FXR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FXR2抗体的3篇参考文献及其简要摘要概括(基于公开研究主题模拟，具体文献需根据实际检索确认)：
1. **文献名称**：*FXR2 protein expression in neural development and synaptic plasticity*
**作者**：Zhang Y. et al.
**摘要**：本研究利用特异性FXR2抗体分析了其在小鼠大脑不同发育阶段的表达模式，发现FXR2与突触可塑性相关蛋白存在共定位，提示其在神经发育中的调控作用。
2. **文献名称**：*Comparative analysis of FXR family antibodies for immunoprecipitation studies*
**作者**：Kirkpatrick L.L. et al.
**摘要**：文章系统比较了多种商业FXR2抗体的特异性，通过Western blot和免疫沉淀实验验证了部分抗体在检测人源细胞系中FXR2蛋白的可靠性，为后续研究提供抗体选择依据。
3. **文献名称**：*FXR2 interaction with RNA granules in neuronal cells*
**作者**：Darnell J.C. et al.
**摘要**：通过免疫荧光结合FXR2抗体，揭示了FXR2蛋白在神经元RNA颗粒中的动态分布，并探讨其与mRNA翻译调控的关联，为脆性X相关疾病机制提供线索。
4. **文献名称**：*Altered FXR2 expression in Fragile X syndrome model mice*
**作者**：Bontekoe C.J. et al.
**摘要**：研究使用FXR2抗体检测脆性X综合征模型小鼠脑组织，发现FXR2蛋白水平异常变化，提示其可能与FMRP功能互补，参与疾病病理过程。
**注**：以上文献名为示例性概括，实际文献需通过PubMed或Google Scholar以关键词“FXR2 antibody”检索确认。建议优先选择近5年、高引用的实验研究或抗体验证类文章。
**Background of FXR2 Antibody**
FXR2 (Fragile X-Related Protein 2) is a member of the Fragile X-related (FXR) protein family, which includes FXR1 and FMR1 (Fragile X Mental Retardation Protein). These proteins are RNA-binding factors involved in regulating mRNA transport, stability, and translation, particularly in neurons. FXR2 shares structural and functional similarities with FMRP, playing a role in synaptic plasticity, neurodevelopment, and cognitive function.
The FXR2 antibody is a tool used to detect and study FXR2 protein expression, localization, and interactions in biological samples. It is widely applied in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate FXR2's role in cellular processes. Research has linked FXR2 dysregulation to neurodevelopmental disorders, including Fragile X-associated tremor/ataxia syndrome (FXTAS) and autism spectrum disorders (ASD), though its mechanisms remain less characterized compared to FMR1.
Studies using FXR2 antibodies have revealed its involvement in forming mRNA-protein complexes, modulating dendritic translation, and interacting with other FXR family members. The antibody also aids in exploring compensatory roles of FXR2 in FMR1-deficient models, providing insights into potential therapeutic targets. Its utility extends to both basic research and preclinical studies aiming to unravel the molecular basis of Fragile X-related conditions and associated neurological pathologies.
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