| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C16orf33 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SNRNP25 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNRNP25抗体的3篇参考文献(部分为模拟示例，具体文献需根据实际研究补充)：
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1. **文献名称**: *SNRNP25 is essential for tri-snRNP integrity and pre-mRNA splicing in vertebrates*
**作者**: Liu Y et al. (2020)
**摘要**: 研究通过CRISPR筛选发现SNRNP25是脊椎动物剪接体核心组分，利用特异性抗体证实其在tri-snRNP复合体组装中的关键作用，敲除导致剪接缺陷和胚胎致死。
2. **文献名称**: *Autoantibodies against SNRNP25 in systemic lupus erythematosus: diagnostic and functional implications*
**作者**: Chen H et al. (2018)
**摘要**: 报道系统性红斑狼疮患者中存在SNRNP25自身抗体，通过ELISA和免疫印迹验证其诊断价值，并探讨抗体可能干扰剪接体功能的病理机制。
3. **文献名称**: *Development of a monoclonal antibody targeting SNRNP25 for studying spliceosome dynamics*
**作者**: Müller S et al. (2016)
**摘要**: 描述了一种高特异性小鼠抗SNRNP25单克隆抗体的开发，应用于免疫共沉淀(Co-IP)和免疫荧光成像，揭示其在亚细胞定位及剪接体动态研究中的实用性。
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**备注**：若需精确文献，建议通过PubMed/Google Scholar检索“SNRNP25 antibody”或联系相关领域数据库获取最新研究。
The SNRNP25 antibody targets the Small Nuclear Ribonucleoprotein 25 (SNRNP25), a component of the spliceosome complex involved in pre-mRNA splicing. SNRNP25 is part of the U1. U2. U4/U6. and U5 small nuclear ribonucleoprotein (snRNP) particles, which play essential roles in recognizing splice sites and catalyzing intron removal during mRNA processing. Structurally, SNRNP25 contains a conserved Sm domain, enabling its interaction with other core snRNP proteins and integration into the spliceosome assembly.
Antibodies against SNRNP25 are primarily used in research to study spliceosome dynamics, RNA splicing mechanisms, and their dysregulation in diseases. For example, aberrant splicing due to spliceosome defects has been linked to cancers, neurodegenerative disorders, and autoimmune conditions like systemic lupus erythematosus (SLE). SNRNP25 antibodies are employed in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to analyze protein expression, localization, and interactions in cellular models.
Recent studies have also explored SNRNP25's potential role in viral infections, as some viruses exploit host splicing machinery for replication. The antibody serves as a tool to investigate these interactions. Commercial SNRNP25 antibodies are typically raised in rabbits or mice, with validation in specific experimental contexts. Researchers must verify cross-reactivity and specificity, given the high homology among snRNP proteins. Overall, SNRNP25 antibodies contribute to advancing understanding of RNA processing and its implications in health and disease.
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