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Rabbit Polyclonal JPT2 Antibody

  • 中文名: JPT2抗体
  • 别    名: L11; HN1L; C16orf34
货号: IPDX09848
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesL11; HN1L; C16orf34
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human JPT2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于JPT2抗体的假设性参考文献示例,格式包含文献名称、作者及简要摘要内容:

1. **文献名称**:*"A Novel Monoclonal Antibody Against JPT2 Reveals Its Role in Cardiac Muscle Function"*

**作者**:Zhang Y, et al.

**摘要**:该研究报道了一种新型JPT2单克隆抗体的开发,验证其在心脏组织中的特异性结合能力,并证实JPT2在维持心肌细胞钙离子稳态中的关键作用,为心脏疾病机制研究提供工具。

2. **文献名称**:*"JPT2 Antibody-Based Detection of Synaptic Protein Localization in Neuronal Cells"*

**作者**:Martinez R, et al.

**摘要**:通过免疫荧光和共聚焦显微镜技术,利用JPT2抗体揭示了其在神经元突触中的定位,表明JPT2可能参与神经递质释放调控,为神经退行性疾病研究提供新方向。

3. **文献名称**:*"Validation of a High-Affinity JPT2 Polyclonal Antibody for Immunohistochemical Applications"*

**作者**:Kim H, et al.

**摘要**:研究团队验证了一种高亲和力JPT2多克隆抗体,优化其用于福尔马林固定石蜡包埋组织的免疫组化分析,成功在多种癌症组织中检测到JPT2异常表达。

4. **文献名称**:*"JPT2 Knockout Model and Antibody-Based Phenotypic Rescue in Zebrafish"*

**作者**:Chen L, et al.

**摘要**:利用CRISPR技术构建斑马鱼JPT2敲除模型,并结合JPT2抗体进行表型分析,证明JPT2缺失导致肌肉发育缺陷,抗体辅助的蛋白回补实验部分恢复表型,提示其治疗潜力。

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**注**:以上内容为模拟生成,实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。若JPT2为特定领域术语,建议结合全称或相关基因名(如Junctophilin-2/JPH2)进一步查询。

背景信息

The JPT2 antibody targets Junction Plakoglobin (JUP), also known as γ-catenin, a key component of cell-cell adhesion structures like desmosomes and adherens junctions. JUP plays dual roles: it stabilizes intercellular connections by linking cadherins to the actin cytoskeleton and participates in Wnt/β-catenin signaling, influencing cell proliferation and differentiation. Dysregulation of JUP is implicated in pathologies such as arrhythmogenic cardiomyopathy (AC), where mutations disrupt desmosomal integrity, leading to fibrofatty myocardial replacement. In cancer, reduced JUP expression correlates with epithelial-mesenchymal transition (EMT), metastasis, and poor prognosis, particularly in carcinomas. The JPT2 antibody is widely utilized in research to visualize JUP localization via immunofluorescence or immunohistochemistry, assess protein levels in Western blotting, and investigate molecular mechanisms in disease models. Its applications extend to studying desmosomal disorders, cardiac pathologies, and cancer biology, making it a critical tool for exploring cell adhesion dynamics and signaling pathways. Commercial JPT2 antibodies are typically raised in rabbits or mice, validated for reactivity in human, mouse, and rat tissues.

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