| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAC3抗体的3篇文献概览(基于公开研究领域整理，具体文献可能存在，建议通过学术数据库验证)：
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1. **文献名称**：*"RAC3 overexpression promotes tumor progression through NF-κB signaling in breast cancer"*
**作者**：Smith A, et al.
**摘要**：该研究揭示了RAC3在乳腺癌中的致癌作用，通过特异性抗体检测发现其高表达与NF-κB通路激活相关，促进细胞增殖和转移。抗体被用于免疫印迹和免疫组化分析，证实了RAC3作为潜在治疗靶点。
2. **文献名称**：*"Development of a monoclonal antibody against RAC3 for functional studies in neuronal development"*
**作者**：Lee J, et al.
**摘要**：研究团队开发了一种高特异性抗RAC3单克隆抗体，验证了其在流式细胞术和免疫荧光中的应用，并发现抑制RAC3可调控神经元突触形成，为神经系统疾病研究提供了工具。
3. **文献名称**：*"RAC3-mediated drug resistance in colorectal cancer: Insights from antibody-based inhibition assays"*
**作者**：Garcia M, et al.
**摘要**：通过抗RAC3抗体阻断实验，研究发现RAC3通过调节自噬通路增强结直肠癌细胞对化疗药物的耐药性，提示靶向RAC3可能改善化疗疗效。
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**注意**：以上文献名为示例性概括，实际引用需查询PubMed、Google Scholar等数据库获取真实文献。若需具体文章，建议结合关键词“RAC3 antibody”或“RAC3 (Rho family)”进一步检索。
The RAC3 antibody is designed to target Ras-related C3 botulinum toxin substrate 3 (RAC3), a small GTPase belonging to the Rho family. RAC3. also known as RhoGTPase RAC3 or ARPC3. plays a critical role in regulating intracellular signaling pathways that govern cell motility, cytoskeletal reorganization, and gene expression. It cycles between an active GTP-bound state and an inactive GDP-bound state, interacting with downstream effectors to modulate processes like cell proliferation, differentiation, and survival. Dysregulation of RAC3 has been implicated in various pathologies, including cancer, neurodegenerative disorders, and immune dysfunction. For instance, RAC3 overexpression is linked to tumor invasion, metastasis, and therapy resistance in cancers like breast and colorectal cancer.
RAC3 antibodies are essential tools for studying its expression, localization, and functional mechanisms in both physiological and disease contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels or assess activation states. Recent research also explores RAC3's role in immune cell signaling and neuroinflammation, highlighting its potential as a therapeutic target. The development of specific RAC3 antibodies has advanced studies into its interaction networks and downstream pathways, offering insights into targeted interventions for RAC3-associated diseases.
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