| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TEX4; TIM22 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TIMM22 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TIMM22抗体的3篇参考文献及其摘要概括：
---
1. **文献名称**：*TIMM22 is essential for the assembly and stability of the mitochondrial protein import complex*
**作者**：Rehling, P., et al.
**摘要**：研究通过免疫共沉淀和Western blot技术，利用TIMM22抗体揭示了TIMM22在线粒体内膜转位酶复合体组装中的关键作用，证明其缺失会导致线粒体蛋白输入功能受损。
---
2. **文献名称**：*Dysregulation of mitochondrial protein import in Parkinson's disease models*
**作者**：Smith, J.G., et al.
**摘要**：该研究使用TIMM22抗体检测帕金森病模型中线粒体蛋白输入复合体的表达变化，发现TIMM22水平降低与α-突触核蛋白毒性导致的线粒体功能障碍相关。
---
3. **文献名称**：*Structural insights into the TIM22 complex by cryo-EM*
**作者**：Zhang, Y., et al.
**摘要**：通过冷冻电镜技术结合TIMM22抗体的免疫标记，解析了TIM22复合体的三维结构，阐明了其介导跨膜蛋白折叠与转运的分子机制。
---
(注：以上文献信息为示例性概括，实际文献需通过数据库如PubMed检索确认。)
The TIMM22 (Translocase of Inner Mitochondrial Membrane 22) antibody is a tool used to study the TIMM22 protein, a key component of the mitochondrial TIM22 complex. TIMM22 plays a critical role in the import and insertion of hydrophobic carrier proteins into the mitochondrial inner membrane. These carrier proteins are essential for metabolic processes, including ATP/ADP exchange, amino acid transport, and ion homeostasis. The TIM22 complex, anchored by TIMM22. facilitates the assembly of these proteins into the membrane, ensuring proper mitochondrial function and energy production.
Antibodies targeting TIMM22 are widely used in research to investigate mitochondrial protein import mechanisms, mitochondrial dysfunction, and associated diseases such as neurodegenerative disorders, metabolic syndromes, and cancer. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess TIMM22 expression, localization, and interactions. Studies using TIMM22 antibodies have highlighted its role in maintaining mitochondrial membrane potential and its involvement in stress responses.
TIMM22 antibodies are typically validated for specificity across species, including human, mouse, and rat models. Researchers rely on these reagents to explore mitochondrial biology, disease pathways, and therapeutic targets, emphasizing their importance in understanding cellular energy regulation and pathology.
×
