| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AYTL1; AGPAT11; LysoPAFAT |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LPCAT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LPCAT2抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
1. **文献名称**：*LPCAT2 regulates oxidized phospholipid-induced inflammation in macrophages*
**作者**：Li Z, et al.
**摘要**：该研究发现LPCAT2通过调控氧化磷脂的生物合成，促进巨噬细胞中促炎细胞因子(如IL-6和TNF-α)的产生，利用LPCAT2抗体证实其在炎症信号通路中的关键作用。
2. **文献名称**：*Role of LPCAT2 in the synthesis of pro-inflammatory lipids in atherosclerosis*
**作者**：Huang L, et al.
**摘要**：研究通过免疫组化及Western blot(使用LPCAT2特异性抗体)证明，LPCAT2在动脉粥样硬化斑块中高表达，并通过生成促炎脂质介质加速疾病进展。
3. **文献名称**：*LPCAT2 inhibition attenuates acute lung injury via modulating lipid metabolism*
**作者**：Wang Y, et al.
**摘要**：该研究利用LPCAT2中和抗体在小鼠模型中抑制酶活性，发现其可减少肺组织炎症细胞浸润和脂质过氧化，提示LPCAT2是治疗急性肺损伤的潜在靶点。
(注：以上文献信息为示例性质，具体内容需根据实际发表论文调整。)
The LPCAT2 (lysophosphatidylcholine acyltransferase 2) antibody is a tool used to detect and study the LPCAT2 enzyme, a key player in phospholipid remodeling. LPCAT2 belongs to the acyltransferase family and catalyzes the conversion of lysophosphatidylcholine (LPC) to phosphatidylcholine (PC) by transferring acyl groups, a critical step in maintaining membrane composition and lipid signaling. This enzyme is also involved in synthesizing platelet-activating factor (PAF), a potent lipid mediator linked to inflammation, immune responses, and vascular permeability. LPCAT2 is highly expressed in immune cells, such as macrophages and neutrophils, and its activity has been implicated in inflammatory diseases, atherosclerosis, and cancer progression.
Antibodies targeting LPCAT2 enable researchers to investigate its expression, localization, and regulatory mechanisms in various tissues and disease models. These antibodies are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Specificity is crucial, as LPCAT2 shares structural homology with other acyltransferases (e.g., LPCAT1). High-quality antibodies help distinguish LPCAT2’s unique roles in lipid metabolism and inflammation-related pathways. Recent studies highlight its potential as a therapeutic target, particularly in conditions driven by lipid dysregulation or chronic inflammation. However, its dual roles in pro-inflammatory and homeostatic processes necessitate precise detection tools to unravel context-dependent functions.
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