Rabbit Polyclonal EXD2 Antibody

The EXD2 antibody is a research tool designed to target the EXD2 protein, a conserved eukaryotic enzyme implicated in DNA repair and mitochondrial function. Initially characterized for its 3'-5' exonuclease activity, EXD2 (Exonuclease 3'-5' Domain-containing 2) is thought to play dual roles in nuclear DNA damage response and mitochondrial RNA processing. Studies link EXD2 to homologous recombination repair, where it interacts with proteins like BRCA2 to resolve DNA replication stress, suggesting potential relevance in cancer biology. Additionally, EXD2 localizes to mitochondria, participating in ribosomal RNA maturation and respiratory chain assembly. Antibodies against EXD2 are primarily used in Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, subcellular distribution, and molecular interactions. Research has explored EXD2's overexpression in certain tumors and its association with poor prognosis, positioning it as a possible biomarker or therapeutic target. However, its precise mechanisms remain under study, particularly regarding its nuclear-mitochondrial functional crosstalk. Commercial EXD2 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout cell lines to confirm specificity. Ongoing work aims to clarify EXD2's role in genome stability, metabolic regulation, and disease pathways.