| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | 5-LO, 5LPG, LOG5, 5-LOX |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ALOX5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于FNTB(法尼基转移酶β亚基)抗体的参考文献示例及摘要概括，基于公开研究方向的合理推测整理：
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1. **文献名称**：*Development of a Monoclonal Antibody Targeting FNTB for Inhibition of Ras Signaling in Cancer*
**作者**：Zhang Y, et al.
**摘要**：本研究开发了一种高特异性的抗FNTB单克隆抗体，验证其通过抑制法尼基转移酶活性阻断Ras蛋白的膜定位，从而抑制多种癌细胞系的增殖和体内肿瘤生长，为靶向Ras通路的治疗提供了新策略。
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2. **文献名称**：*FNTB Expression in Neurodegenerative Disorders: An Immunohistochemical Study Using Novel Antibody Probes*
**作者**：Lee S, Kim JH.
**摘要**：研究者利用新型FNTB抗体，通过免疫组化和Western blot分析了阿尔茨海默病模型小鼠脑组织中FNTB的表达变化，发现其异常上调可能与tau蛋白异常修饰相关，提示FNTB在神经退行性疾病中的潜在作用。
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3. **文献名称**：*Structural Insights into Farnesyltransferase Beta Subunit (FNTB) via Antibody-Mediated Crystallography*
**作者**：Gupta R, et al.
**摘要**：该研究通过结合FNTB特异性抗体的冷冻电镜技术，解析了FNTB与底物的复合物结构，揭示了其催化口袋的关键氨基酸残基，为设计小分子抑制剂或抗体药物提供了结构基础。
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**注**：以上文献为示例性整理，实际引用需以具体发表的论文为准。建议通过PubMed或Web of Science以“FNTB antibody”“farnesyltransferase beta”等关键词检索最新文献。
**Background of FNTB Antibody**
The **Farnesyltransferase Beta Subunit (FNTB)** is a critical enzyme component of farnesyltransferase, which catalyzes the post-translational modification of proteins by attaching farnesyl groups to cysteine residues. This process, known as farnesylation, is essential for membrane localization and activation of signaling proteins like Ras, which play pivotal roles in cell proliferation, survival, and differentiation. Dysregulation of FNTB has been implicated in cancers and neurodegenerative disorders due to its role in Ras pathway activation and improper protein trafficking.
**FNTB antibodies** are immunological tools designed to detect and quantify FNTB expression in research and diagnostic settings. They enable the study of FNTB's involvement in disease mechanisms, particularly in oncogenesis, where aberrant Ras signaling is common. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels, cellular localization, and interaction partners. Additionally, FNTB antibodies support therapeutic development, as farnesyltransferase inhibitors (FTIs) are explored for targeting Ras-driven cancers. Their specificity and reliability make them crucial for validating FNTB as a biomarker or therapeutic target in preclinical studies.
In summary, FNTB antibodies serve as vital reagents for understanding protein prenylation biology and advancing research into diseases linked to FNTB dysfunction.
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