| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LH2; TLH; BRKS2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PLOD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLOD2抗体的3篇参考文献示例(内容为模拟生成，仅供参考)：
1. **文献名称**：*PLOD2 promotes collagen hydroxylation and metastasis in breast cancer*
**作者**：Smith A, et al.
**摘要**：研究通过PLOD2特异性抗体检测发现，PLOD2在乳腺癌组织中高表达，并通过羟化胶原促进肿瘤细胞侵袭和转移，提示其作为预后标志物的潜力。
2. **文献名称**：*Antibody-based targeting of PLOD2 in fibrotic liver disease*
**作者**：Chen L, et al.
**摘要**：利用PLOD2抗体进行免疫组化分析，证实PLOD2在肝纤维化模型中的上调表达，抑制其活性可减少胶原沉积，为抗纤维化治疗提供新策略。
3. **文献名称**：*PLOD2 regulates tumor microenvironment via collagen remodeling in osteosarcoma*
**作者**：Wang Y, et al.
**摘要**：通过Western blot和免疫荧光技术(使用PLOD2抗体)，揭示PLOD2通过调控胶原交联影响骨肉瘤的肿瘤微环境，促进血管生成和耐药性。
**提示**：建议通过PubMed或Google Scholar搜索最新文献，使用关键词“PLOD2 antibody”或“PLOD2 in cancer/fibrosis”获取准确信息。
PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), also known as lysyl hydroxylase 2 (LH2), is an enzyme encoded by the PLOD2 gene. It plays a critical role in collagen biosynthesis by catalyzing the hydroxylation of lysine residues in collagen telopeptides, a post-translational modification essential for the formation of stable collagen cross-links. This process influences collagen fibril organization and tissue mechanical properties. PLOD2 is primarily expressed in connective tissues, bones, and organs rich in collagen, such as skin and tendons. Dysregulation of PLOD2 has been implicated in pathological conditions, including cancer metastasis, fibrosis, and connective tissue disorders like Bruck syndrome.
PLOD2 antibodies are immunological tools designed to detect and quantify PLOD2 protein expression in research settings. They are widely used in studies exploring tumor microenvironment remodeling, as PLOD2 overexpression in cancer cells promotes collagen cross-linking, facilitating invasion and metastasis. These antibodies are also applied in fibrosis research, where aberrant PLOD2 activity contributes to excessive collagen deposition. Available in formats like monoclonal or polyclonal antibodies, they support techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Commercial PLOD2 antibodies are often validated for specificity and sensitivity, aiding in mechanistic studies of collagen-related diseases and potential therapeutic targeting. Their utility extends to biomarker discovery and preclinical drug development.
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