| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CHDC2; CXorf22; CXorf30; CXorf59 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CFAP47 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CFAP47抗体相关的参考文献及其简要摘要：
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1. **文献名称**: *CFAP47 is a novel ciliary protein involved in male infertility and sperm motility regulation*
**作者**: Wang, Y., et al. (2021)
**摘要**: 本研究利用CRISPR/Cas9技术构建了CFAP47基因敲除小鼠模型，并通过免疫荧光和Western blot验证了抗体的特异性。发现CFAP47缺陷导致精子鞭毛结构异常和运动能力下降，提示其在男性不育中的潜在作用。
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2. **文献名称**: *Characterization of CFAP47 antibody for detecting ciliopathy-related cellular phenotypes*
**作者**: Lee, S., & Chen, J. (2019)
**摘要**: 文章报道了一种新型CFAP47多克隆抗体的开发，通过免疫组化、流式细胞术验证其特异性。实验表明CFAP47在纤毛基体区域高表达，其缺失与纤毛长度异常和信号传导功能障碍相关。
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3. **文献名称**: *CFAP47 mutations cause severe asthenoteratozoospermia in humans and mice*
**作者**: Zhang, X., et al. (2020)
**摘要**: 研究者通过全外显子测序发现CFAP47基因突变与人类弱畸精子症相关，并利用抗体进行患者精子蛋白表达分析，发现突变导致CFAP47蛋白显著减少，影响鞭毛轴丝组装。
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注：以上文献为示例，实际引用需以具体数据库(如PubMed、Google Scholar)检索结果为准。建议结合关键词“CFAP47 antibody”、“sperm motility”或“ciliopathy”进一步筛选近期研究。
The CFAP47 antibody is designed to target the Cilia and Flagella Associated Protein 47 (CFAP47), a protein implicated in the structure and function of motile cilia and flagella. CFAP47 is part of a conserved protein family involved in ciliary motility, which plays critical roles in cellular movement, fluid propulsion, and sensory signaling. Mutations in CFAP47 or related genes have been linked to ciliopathies, such as primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, recurrent respiratory infections, and infertility due to defective sperm flagella or ciliary dysfunction in fallopian tubes.
Research on CFAP47 has focused on its localization within the axoneme—the microtubule-based core of cilia and flagella—and its interaction with other dynein-associated proteins to regulate ciliary beating. The CFAP47 antibody is a vital tool for studying these mechanisms, enabling detection and visualization of the protein via techniques like immunofluorescence, Western blotting, or immunohistochemistry. It has been utilized in both clinical and basic research settings to explore CFAP47 expression patterns in tissues such as respiratory epithelia, sperm cells, and model organisms (e.g., mice, zebrafish). Studies using this antibody contribute to understanding ciliary biology, disease pathogenesis, and potential therapeutic strategies for ciliopathies.
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