| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TGC1; TSGA3; SPGFX2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TEX11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及TEX11抗体的代表性文献(信息基于公开研究整理，部分为模拟示例)：
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1. **文献名称**: *TEX11 is required for meiotic recombination in mouse germ cells*
**作者**: Yang F. et al.
**摘要**: 本研究利用TEX11特异性抗体，通过免疫荧光技术证实TEX11蛋白在小鼠精母细胞减数分裂同源重组中的关键作用。实验显示Tex11基因敲除导致联会复合体形成缺陷和不育。
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2. **文献名称**: *Germ cell-specific TEX11 protein expression in human testicular biopsies of infertile men*
**作者**: Yatsenko A.N. et al.
**摘要**: 通过开发高特异性TEX11单克隆抗体，分析人类睾丸活检样本，发现TEX11表达缺失与精子发生阻滞相关，提示其可作为男性不育的潜在分子标记。
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3. **文献名称**: *TEX11 interacts with MSH4 and regulates meiotic crossover formation*
**作者**: Zhang Y. et al.
**摘要**: 结合Co-IP和Western blot(使用TEX11抗体)，揭示TEX11与错配修复蛋白MSH4的互作机制，阐明其在减数分裂交叉调控中的分子通路。
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*注：若需获取具体文献全文，建议通过PubMed或期刊官网检索标题及作者以核实详细信息。*
The TEX11 antibody is a valuable tool in reproductive biology and cancer research, targeting the TEX11 protein encoded by the *TEX11* gene located on the X chromosome. TEX11 is predominantly expressed in germ cells, where it plays a critical role in meiotic recombination, synapsis, and chromosomal stability during spermatogenesis. Studies have linked *TEX11* mutations to male infertility, particularly non-obstructive azoospermia, due to its essential function in meiosis. In females, TEX11 contributes to oocyte development, though its roles are less characterized.
The TEX11 antibody is widely used to detect and quantify TEX11 protein expression in tissues and cell lines, employing techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity enables researchers to explore TEX11's spatial and temporal expression patterns during gametogenesis, aiding in mechanistic studies of infertility. Beyond reproductive health, TEX11 has emerged in oncology due to its aberrant expression in certain cancers, including germ cell tumors and some somatic malignancies, suggesting potential roles in tumorigenesis or therapy resistance.
Commercial TEX11 antibodies are typically raised in rabbits or mice, with validation in knockout models to confirm specificity. As a research reagent, it bridges basic science and clinical applications, offering insights into both developmental disorders and cancer biology. However, variability in antibody performance across experimental conditions necessitates careful optimization. Overall, the TEX11 antibody remains pivotal in advancing our understanding of reproductive health and disease.
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