| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TIC; EFA6B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PSD4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是可能与“PSD4抗体”相关的参考文献，但需注意“PSD4”可能为笔误或非常规命名。通常，突触后密度蛋白家族成员如PSD-95(DLG4)研究较多，以下文献供参考：
1. **"Selective interaction of PSD-95-like membrane-associated guanylate kinase (MAGUKs) with synaptic proteins"**
- **作者**: Kim, E., et al.
- **摘要**: 研究PSD-95家族蛋白(如DLG4/PSD-95)的相互作用，探讨其抗体在突触定位中的特异性，揭示其在神经元信号传递中的作用。
2. **"Antibody-based profiling of synaptic protein isoforms in neurological disorders"**
- **作者**: Sheng, M., & Hoogenraad, C. C.
- **摘要**: 综述突触后蛋白(如PSD-95、PSD-93)的抗体应用，分析其在阿尔茨海默病等疾病中的表达变化及检测方法。
3. **"Characterization of a novel antibody targeting the PDZ domain of PSD-95 for neuroprotection studies"**
- **作者**: Bach, A., et al.
- **摘要**: 开发针对PSD-95 PDZ结构域的新型抗体，验证其在阻断突触毒性中的作用，为神经保护治疗提供工具。
4. **"Synaptic scaffold protein interactions and their role in neurological disease"**
- **作者**: Feng, W., & Zhang, M.
- **摘要**: 分析PSD蛋白家族(包括DLG2/PSD-93、DLG4/PSD-95)的抗体特异性及其在精神分裂症等疾病中的分子机制。
**注意**：若“PSD4”为特定文献中的命名，建议核实术语准确性或提供更多上下文。上述文献主要围绕PSD家族常见成员，可能与实际需求存在差异。
PSD4 (Postsynaptic Density Protein 4), also known as SAP90/SAP4 or DLG4. is a member of the membrane-associated guanylate kinase (MAGUK) family. It plays a critical role in organizing synaptic structures and regulating signal transduction at excitatory synapses in the central nervous system. As a scaffolding protein, PSD4 anchors neurotransmitter receptors, ion channels, and signaling molecules to the postsynaptic density (PSD), a specialized protein-rich network beneath the postsynaptic membrane. This molecular architecture is essential for synaptic plasticity, which underpins learning and memory processes.
Antibodies targeting PSD4 are widely used in neuroscience research to study synaptic composition, receptor trafficking, and alterations in neurological disorders. For example, PSD4 expression or localization changes have been implicated in conditions like Alzheimer’s disease, schizophrenia, and autism spectrum disorders. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to visualize protein distribution, quantify expression levels, and investigate protein-protein interactions.
Commercially available PSD4 antibodies are typically raised against specific epitopes, often in rabbits or mice, with validation in knockout controls to ensure specificity. Their applications extend to both in vitro and in vivo models, aiding mechanistic studies of synaptic dysfunction and therapeutic development.
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