Rabbit Polyclonal ZNF471 Antibody

The ZNF471 antibody is a research tool designed to detect and study the zinc finger protein 471 (ZNF471), a member of the Krüppel-associated box (KRAB) zinc finger protein (ZFP) family. ZNF471 is encoded by a gene located on human chromosome 19q13.12 and is characterized by multiple C2H2-type zinc finger motifs, which enable sequence-specific DNA binding. KRAB-ZFPs, including ZNF471. are primarily involved in transcriptional regulation, often acting as repressors by recruiting chromatin-modifying complexes to mediate epigenetic silencing. Dysregulation of ZNF471 has been implicated in cancer, with studies suggesting its role as a tumor suppressor. For instance, promoter hypermethylation of ZNF471 has been observed in various malignancies, correlating with reduced expression and potential involvement in tumorigenesis. The ZNF471 antibody facilitates investigations into its expression patterns, subcellular localization, and interactions in both normal and pathological contexts. Researchers employ this antibody in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ZNF471's biological functions, particularly its regulatory roles in cell differentiation, proliferation, and apoptosis. Its development underscores the growing interest in epigenetic regulators and their therapeutic potential in diseases like cancer. However, the precise molecular mechanisms and full spectrum of ZNF471's activities remain under active investigation.