| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PZR; PZRa; PZRb; PZR1b; MPZL1b |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MPZL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与MPZL1抗体相关的文献示例(注：文献信息为虚构模拟，仅作格式参考)：
1. **标题**：MPZL1 as a Novel Biomarker in Hepatocellular Carcinoma: Antibody Development and Clinical Validation
**作者**：Chen L, et al.
**摘要**：本研究开发了高特异性MPZL1单克隆抗体，证实其在肝癌组织中异常高表达，并与患者预后不良相关。抗体可用于免疫组化检测，为肝癌诊断提供新工具。
2. **标题**：Structural Characterization of MPZL1 Extracellular Domain Using Cryo-EM with Specific Antibody Probes
**作者**：Watanabe K, et al.
**摘要**：通过冷冻电镜技术结合抗MPZL1抗体，解析了MPZL1胞外结构域的构象变化，揭示其与ERBB2受体的相互作用机制，为靶向治疗提供结构基础。
3. **标题**：Anti-MPZL1 Antibody-drug Conjugate Shows Efficacy in Triple-negative Breast Cancer Models
**作者**：Rodriguez M, et al.
**摘要**：报道一种新型MPZL1抗体-药物偶联物(ADC)，在临床前实验中显著抑制三阴性乳腺癌的转移，证明MPZL1作为治疗靶点的潜力。
(实际文献需通过PubMed/Google Scholar等平台以"MPZL1 antibody"为关键词检索)
MPZL1 (Myelin Protein Zero-like 1), also known as PZR, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It shares structural homology with Myelin Protein Zero (MPZ), a key component of peripheral nerve myelin. MPZL1 is widely expressed in various tissues, including the liver, breast, and immune cells, and plays roles in cell adhesion, signaling, and immune regulation. Studies suggest its involvement in modulating receptor tyrosine phosphatase activity, particularly interacting with SHP-2 to influence downstream pathways like MAPK/ERK, which are critical for cell proliferation and differentiation.
MPZL1 antibodies are essential tools for investigating its biological functions and disease associations. Research highlights its dual role in cancer: MPZL1 overexpression correlates with poor prognosis in hepatocellular carcinoma and breast cancer, promoting tumor growth and metastasis, while acting as a tumor suppressor in certain contexts. Antibodies targeting MPZL1 enable detection of its expression levels via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding in mechanistic studies and biomarker discovery. Dysregulation of MPZL1 has also been linked to autoimmune disorders and hearing loss, emphasizing its broad pathophysiological relevance. The development of specific MPZL1 antibodies continues to support advances in understanding its complex roles in cellular communication and disease pathogenesis.
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