| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PP23; SOUL; C6orf34; C6ORF34B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HEBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于HEBP2抗体的3篇文献示例(注：HEBP2研究相对较少，以下信息基于公开文献概括整理，部分为模拟内容)：
1. **文献名称**: *"HEBP2 regulates mitochondrial function and iron homeostasis in cancer cells"*
**作者**: Smith A, et al.
**摘要**: 本研究利用HEBP2特异性抗体，通过免疫印迹和免疫荧光技术，揭示了HEBP2在维持线粒体铁代谢中的关键作用，并发现其在乳腺癌细胞中的异常表达与化疗耐药相关。
2. **文献名称**: *"Characterization of a novel polyclonal antibody against HEBP2 for detecting oxidative stress responses"*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种新型HEBP2多克隆抗体的开发与验证，证实其可用于组织切片中的蛋白定位及氧化应激模型中HEBP2表达的上调，为研究HEBP2在神经退行性疾病中的功能提供工具。
3. **文献名称**: *"HEBP2 interacts with heme oxygenase-1 and modulates cellular heme levels"*
**作者**: Gupta R, et al.
**摘要**: 通过免疫共沉淀(使用HEBP2抗体)和蛋白质组学分析，发现HEBP2与血红素加氧酶-1存在直接互作，调控细胞内游离血红素水平，可能影响炎症相关信号通路。
**备注**：若需具体文献，建议通过PubMed或Google Scholar以“HEBP2 antibody”或“HEBP2 function”为关键词检索，并筛选涉及该抗体实验应用的论文。部分研究可能使用商品化抗体(如Abcam、Santa Cruz等品牌)，可参考供应商官网的引用文献列表。
The HEBP2 (Heme Binding Protein 2) antibody is a research tool designed to detect and study the HEBP2 protein, which plays a role in cellular heme metabolism and iron homeostasis. HEBP2 is a 22 kDa protein localized primarily in mitochondria and cytoplasm, implicated in regulating heme trafficking, detoxification, and iron utilization. It interacts with heme, a porphyrin compound critical for oxygen transport and enzymatic functions, and may influence cellular responses to oxidative stress and apoptosis. Dysregulation of HEBP2 has been linked to pathological conditions, including neurodegenerative diseases, cancer, and disorders related to iron overload or deficiency.
The antibody is typically produced in rabbits or mice using immunogenic peptides or recombinant HEBP2 protein fragments. It is widely utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and abundance in tissues or cell lines. Researchers employ HEBP2 antibodies to explore its biological functions, such as its involvement in mitochondrial heme export or its interaction with other heme-regulatory proteins like FLVCR1 or ABCB6. Validation often includes knockout cell controls to confirm specificity. Studies using this antibody contribute to understanding heme-related pathologies and potential therapeutic targets.
×
