| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ERS-24; SEC22L1 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SEC22B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SEC22B抗体的3篇参考文献概览(注：文献为虚拟示例，实际文献需根据具体数据库检索)：
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1. **文献名称**：*SEC22B regulates ER-to-Golgi protein trafficking and autophagy*
**作者**：Diefenbach RJ, et al.
**摘要**：研究通过SEC22B抗体进行免疫印迹和免疫荧光实验，揭示SEC22B在内质网-高尔基体运输及自噬体形成中的关键作用，表明其缺失导致分泌蛋白运输障碍。
2. **文献名称**：*Role of SEC22B in COPII vesicle formation and cargo selection*
**作者**：Petaja-Repo UE, et al.
**摘要**：利用SEC22B特异性抗体结合siRNA技术，证明SEC22B在COPII囊泡组装中与特定跨膜蛋白互作，调控大分子货物的选择性运输。
3. **文献名称**：*SEC22B antibody-based detection of protein interactions in dendritic cells*
**作者**：Laufman O, et al.
**摘要**：通过SEC22B抗体的共聚焦显微镜和免疫沉淀实验，发现SEC22B在树突状细胞抗原呈递过程中与STX5形成复合物，影响MHC-I类分子递呈效率。
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**提示**：实际文献需通过PubMed、Google Scholar等平台以“SEC22B antibody”或“SEC22B function”为关键词检索，重点关注抗体应用(如Western blot、IF)或功能研究的论文。
SEC22B, a member of the SNARE (Soluble NSF Attachment Protein Receptor) protein family, plays a critical role in intracellular membrane trafficking. It mediates vesicle transport between the endoplasmic reticulum (ER) and Golgi apparatus by forming a ternary SNARE complex with Syntaxin-18 and Use1. Additionally, SEC22B participates in unconventional secretion pathways and cross-talk between ER and endosomal/lysosomal compartments, influencing autophagy and immune antigen presentation.
Antibodies targeting SEC22B are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore membrane trafficking dynamics, organelle interactions, and cellular responses to stress. Researchers also employ SEC22B antibodies to investigate pathological mechanisms in cancers, neurodegenerative diseases, and infections where membrane transport is dysregulated. For instance, certain pathogens (e.g., *Legionella pneumophila*) hijack SEC22B-dependent pathways for intracellular survival. Commercial SEC22B antibodies are available from suppliers like Abcam and Cell Signaling Technology, often validated using knockout/knockdown controls to ensure specificity. These reagents continue to advance our understanding of secretory pathways and their therapeutic implications.
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