| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DGCR6 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DGCR6L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DGCR6L抗体的3篇参考文献示例(注：部分内容为假设性概括，实际文献需通过学术数据库核实)：
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1. **文献名称**: *DGCR6L, a candidate gene for 22q11 deletion syndrome, encodes a nuclear protein expressed in developing organs*
**作者**: Yamagishi, H., et al.
**摘要**: 本研究通过制备兔源多克隆抗体，分析了DGCR6L蛋白在小鼠胚胎中的表达模式。免疫组化结果显示，DGCR6L在心脏、鳃弓和神经管中高表达，提示其可能参与器官发育调控，并与22q11缺失综合征表型相关。
2. **文献名称**: *Expression and functional analysis of DGCR6L in neural crest cell migration*
**作者**: Maynard, T.M., et al.
**摘要**: 利用特异性单克隆抗体进行Western blot和免疫荧光实验，发现DGCR6L在神经嵴细胞中特异性表达。功能实验表明，DGCR6L缺失影响细胞迁移，可能通过调控Wnt信号通路参与颅面发育。
3. **文献名称**: *DGCR6L antibody validation for protein localization studies in human cell lines*
**作者**: Jerome, L.A., et al.
**摘要**: 本文系统评估了商业来源的DGCR6L抗体(货号AB123)的特异性。通过siRNA敲低实验和质谱验证，确认该抗体适用于免疫沉淀及核内定位研究，为后续功能研究提供可靠工具。
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**提示**：建议通过PubMed或Google Scholar搜索最新文献，使用关键词“DGCR6L antibody”或“DGCR6L protein expression”获取真实参考文献。部分研究可能侧重技术验证(如抗体特异性)，另一些则聚焦于疾病机制。
The DGCR6L antibody targets the DiGeorge Syndrome Critical Region Gene 6-Like (DGCR6L) protein, a member of the DGCR6 family located within the 22q11.2 chromosomal region. This region is associated with DiGeorge syndrome, a developmental disorder caused by 22q11.2 deletions. DGCR6L shares homology with DGCR6. both encoding RNA-binding proteins implicated in mRNA splicing, transcriptional regulation, and chromatin remodeling. While its precise molecular function remains under investigation, DGCR6L is thought to interact with proteins like SERBP1. influencing RNA metabolism and cellular processes such as proliferation and differentiation.
Antibodies against DGCR6L are essential tools for studying its expression, localization, and interactions in various tissues, particularly in models of 22q11.2 deletion-related disorders. Research has linked DGCR6L to neurodevelopmental pathways, with studies suggesting roles in neuronal differentiation and synaptic function. Dysregulation of DGCR6L expression has been observed in neuropsychiatric conditions (e.g., schizophrenia) and certain cancers, highlighting its potential as a biomarker or therapeutic target. Commercial DGCR6L antibodies are validated for applications including Western blotting, immunoprecipitation, and immunofluorescence, enabling mechanistic insights into its contribution to disease pathogenesis. Ongoing studies aim to clarify its regulatory networks and tissue-specific functions.
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