| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Msl1; U2B'' |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SNRPB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SNRPB2抗体相关的文献摘要信息，供参考：
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1. **文献名称**：*Autoantibodies to snRNP polypeptides in systemic lupus erythematosus*
**作者**：Craft, J. E., et al.
**摘要**：该研究分析了SLE患者血清中针对snRNP蛋白的自身抗体，发现SNRPB2是抗Sm抗体反应的常见靶点。通过免疫印迹实验证实，SNRPB2抗体在SLE患者中具有特异性，可用于临床诊断标志物的研究。
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2. **文献名称**：*The role of SNRPB2 in spliceosome assembly and function*
**作者**：Will, C. L., & Lührmann, R.
**摘要**：文章探讨了SNRPB2在剪接体动态组装中的作用，利用特异性抗体进行免疫沉淀和共聚焦显微镜观察，揭示了SNRPB2与其他snRNP蛋白的相互作用机制，及其在前体mRNA剪切中的关键功能。
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3. **文献名称**：*SNRPB2 overexpression promotes tumorigenesis in colorectal cancer*
**作者**：Kim, S., et al.
**摘要**：研究通过免疫组化(使用SNRPB2抗体)和RNA干扰技术，证明SNRPB2在结直肠癌中高表达，并与肿瘤增殖、转移相关，提示其可作为潜在治疗靶点。
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如需具体文献全文，建议通过PubMed或ResearchGate等平台检索标题或作者获取。
The SNRPB2 antibody targets the Small Nuclear Ribonucleoprotein Polypeptide B'' (SNRPB2), a core component of the spliceosome complex responsible for pre-mRNA splicing. SNRPB2. also known as SNRPB2 or U2B'', is part of the U2 small nuclear ribonucleoprotein (snRNP), which recognizes the branch site within introns during spliceosome assembly. This protein contains RNA-binding domains critical for its interaction with U2 snRNA and other spliceosomal proteins, ensuring precise removal of introns and exon ligation.
Antibodies against SNRPB2 are widely used in molecular biology to study spliceosome dynamics, RNA-protein interactions, and splicing mechanisms. They are essential tools in techniques like immunoprecipitation, Western blotting, and immunofluorescence to detect SNRPB2 expression, localization, and post-translational modifications. Dysregulation of SNRPB2 has been implicated in diseases linked to splicing defects, including cancers and neurodegenerative disorders. Additionally, SNRPB2 is a common autoantigen in autoimmune conditions like systemic lupus erythematosus (SLE), where autoantibodies target snRNP components. Research using SNRPB2 antibodies helps elucidate its role in disease pathogenesis and potential therapeutic targeting. Commercial SNRPB2 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated depletion, ensuring reliability in experimental applications.
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