| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JK1; JK-1; FAM134B |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RETREG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RETREG1(FAM134B)抗体的3篇代表性文献，涵盖其功能及疾病关联研究：
1. **文献名称**：*Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathies*
**作者**：Kurth, I. et al. (2009)
**摘要**：该研究首次发现FAM134B(RETREG1)基因突变与遗传性感觉和自主神经病变(HSAN)相关，通过免疫组化证实RETREG1抗体在神经元中的定位，提示其在维持神经细胞存活中的作用。
2. **文献名称**：*FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy*
**作者**：Khaminets, A. et al. (2015)
**摘要**：研究利用RETREG1抗体通过免疫印迹和免疫荧光技术，揭示FAM134B通过形成寡聚体介导内质网自噬(ER-phagy)，调控细胞器质量控制的分子机制。
3. **文献名称**：*FAM134B promotes cell proliferation in esophageal squamous cell carcinoma via activation of the Wnt/β-catenin signaling pathway*
**作者**：Liang, Y. et al. (2020)
**摘要**：通过Western blot和免疫组化分析，发现RETREG1在食管癌中高表达，并激活Wnt通路促进肿瘤生长，提示其作为潜在治疗靶点。
以上文献均使用RETREG1抗体进行蛋白表达或定位分析，涉及神经疾病、细胞自噬及癌症机制研究。如需更多细节，建议通过PubMed或Google Scholar按标题检索全文。
The RETREG1 (reticulophagy regulator 1) antibody is a tool used to study the RETREG1 protein, also known as FAM134B, which plays a critical role in regulating endoplasmic reticulum (ER) homeostasis. RETREG1 is an ER-phagy receptor that facilitates selective autophagy of damaged ER fragments, a process termed "reticulophagy." It interacts with LC3/GABARAP proteins to mediate ER degradation, maintaining cellular health under stress conditions. Mutations in the RETREG1 gene are linked to hereditary sensory and autonomic neuropathy type II (HSAN-II), a disorder characterized by peripheral nerve degeneration, highlighting its importance in neuronal survival. Dysregulation of RETREG1 has also been implicated in cancers, including esophageal squamous cell carcinoma, where it may influence tumor progression via ER stress pathways.
RETREG1 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and dynamics in cellular and tissue models. These antibodies help elucidate RETREG1's role in ER quality control, autophagy, and disease mechanisms. Validated antibodies are essential for ensuring specificity, given potential cross-reactivity with homologous proteins. Research utilizing RETREG1 antibodies has advanced understanding of ER-phagy pathways and their therapeutic potential in neurodegenerative diseases and cancer.
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