| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AICL, IFNRG1, CLECSF2, HP10085 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CLEC2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HMBOX1抗体的3篇参考文献及其简要摘要(基于公开信息模拟，具体文献需以实际检索为准)：
1. **文献名称**：*HMBOX1 regulates pancreatic β-cell proliferation through the AKT/FOXO1 signaling pathway*
**作者**：Li Y et al.
**摘要**：研究利用HMBOX1特异性抗体检测其在胰岛β细胞中的表达，发现HMBOX1通过调控AKT/FOXO1通路影响细胞增殖，为糖尿病治疗提供潜在靶点。
2. **文献名称**：*The role of HMBOX1 in maintaining telomere stability and its interaction with shelterin complex*
**作者**：Wang X et al.
**摘要**：通过免疫共沉淀(Co-IP)结合HMBOX1抗体，揭示HMBOX1与端粒保护蛋白复合体(shelterin)的相互作用，证明其在端粒稳定性中的关键作用。
3. **文献名称**：*HMBOX1 suppresses hepatocellular carcinoma progression by inhibiting Wnt/β-catenin signaling*
**作者**：Zhang L et al.
**摘要**：研究使用HMBOX1多克隆抗体进行免疫组化分析，发现HMBOX1在肝癌组织中低表达，并通过抑制Wnt通路抑制肿瘤生长，提示其作为预后标志物的潜力。
**注意事项**：
- 以上文献信息为示例，具体内容需通过PubMed、Google Scholar等平台检索确认。
- 实验设计可能涉及抗体来源(如兔源单抗、商业化抗体品牌)及验证方法(如Western blot/IF特异性验证)，需根据实际文献补充细节。
The HMBOX1 (Homeobox containing 1) antibody targets a protein encoded by the HMBOX1 gene, which belongs to the homeobox family of genes. These genes are characterized by a conserved DNA-binding homeodomain and play critical roles in developmental regulation and cellular differentiation. HMBOX1. also known as PBXIP1 or HPIP, is a nuclear protein implicated in diverse biological processes, including telomere maintenance, cell proliferation, apoptosis, and transcriptional regulation. Emerging studies suggest its involvement in cancer progression (e.g., liver, gastric, and breast cancers), immune modulation, and stem cell properties, though its precise mechanisms remain under investigation.
HMBOX1 antibodies are primarily used in research to detect and quantify HMBOX1 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically produced in immunized hosts (e.g., rabbits or mice) using recombinant HMBOX1 protein fragments or synthetic peptides as antigens. Validation includes specificity checks through knockdown/knockout controls and cross-reactivity assessments.
The interest in HMBOX1 stems from its potential as a biomarker or therapeutic target. Dysregulated HMBOX1 expression has been linked to tumorigenesis, chemoresistance, and immune evasion. For instance, HMBOX1 may interact with telomerase or modulate Wnt/β-catenin signaling, influencing cancer cell survival. Researchers rely on HMBOX1 antibodies to explore these pathways, aiming to uncover novel diagnostic or treatment strategies for HMBOX1-associated diseases.
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