关键信息
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基因名
MMP-13
- 应用
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别名
CLG3; Collagenase 3
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种属
Rat
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P23097
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表达区间
Leu14~Cys466
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分子量
60kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MMP-13, or Matrix Metalloproteinase-13, is a critical enzyme involved in the degradation of extracellular matrix components, particularly collagens, which play essential roles in tissue remodeling and repair. It is primarily expressed in cartilage and is crucial for maintaining joint health; however, its overexpression is associated with various pathological conditions, including osteoarthritis, rheumatoid arthritis, and certain cancers. Research into MMP-13 has gained momentum due to its potential as a therapeutic target for these diseases. The recombinant protein version of MMP-13 allows for detailed studies of its structure-function relationships, regulation, and interaction with other proteins, providing insights into its role in disease processes. Moreover, the development of MMP-13 inhibitors holds promise for treating degenerative diseases and preventing cancer metastasis. Understanding MMP-13's activity through recombinant protein studies can pave the way for novel drug discovery and development, underscoring the importance of this enzyme in medical research and therapeutic interventions.
