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Rabbit Polyclonal TRAPPC1 Antibody

  • 中文名: TRAPPC1抗体
  • 别    名: BET5; MUM2
货号: IPDX10092
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesBET5; MUM2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human TRAPPC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及TRAPPC1抗体的参考文献及其简要摘要:

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1. **文献名称**: *TRAPPC1 regulates osteosarcoma progression through the YAP signaling pathway*

**作者**: Li X, et al.

**摘要**: 该研究利用TRAPPC1特异性抗体进行免疫印迹分析,发现TRAPPC1通过调控Hippo-YAP通路影响骨肉瘤细胞的增殖和迁移,提示其作为潜在治疗靶点。

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2. **文献名称**: *TRAPPC1 deficiency disrupts Golgi structure and leads to congenital microcephaly in mice*

**作者**: Zhang Y, et al.

**摘要**: 通过TRAPPC1抗体免疫荧光染色,作者揭示TRAPPC1缺失导致小鼠高尔基体结构异常,进而引发神经元发育缺陷和小头畸形,强调了其在神经发育中的关键作用。

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3. **文献名称**: *Prognostic value of TRAPPC1 expression in colorectal cancer identified by immunohistochemistry*

**作者**: Wang H, et al.

**摘要**: 研究使用TRAPPC1抗体对结直肠癌组织进行免疫组化分析,发现高表达TRAPPC1与患者生存期缩短显著相关,提示其可作为预后标志物。

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(注:以上文献为模拟示例,实际引用时需核对真实文献信息。)

背景信息

The TRAPPC1 (Trafficking Protein Particle Complex subunit 1) antibody is a tool used to study the TRAPP (TRAnsport Protein Particle) complex, a conserved multi-subunit assembly critical for intracellular membrane trafficking. TRAPPC1. a core component of the TRAPP I complex, facilitates vesicle-mediated transport between the endoplasmic reticulum and Golgi apparatus by acting as a guanine nucleotide exchange factor (GEF) for Rab GTPases like Rab1. Dysregulation of TRAPPC1 is linked to neurodevelopmental disorders, cancer, and ciliopathies, underscoring its role in cellular homeostasis. Researchers use TRAPPC1 antibodies in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions. These studies aim to elucidate mechanisms underlying diseases like autosomal recessive mental retardation 35 (MRT35) and medulloblastoma. Commercially available TRAPPC1 antibodies are typically raised in rabbits or mice against specific epitopes, validated for specificity via knockout controls. Recent studies also explore its involvement in autophagy and cell cycle regulation. As a biomarker, TRAPPC1 expression levels may correlate with disease progression, making its antibody valuable for diagnostic and therapeutic research.

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