| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C19orf57 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C19orf57抗体的3篇参考文献示例(注：内容为虚构，仅供格式参考)：
1. **文献名称**：*C19orf57 regulates mitochondrial RNA metabolism and its deficiency causes developmental defects*
**作者**：Smith J, Lee K, et al.
**摘要**：本研究通过C19orf57抗体进行免疫印迹和免疫荧光实验，发现C19orf57蛋白定位于线粒体，参与线粒体RNA的加工。基因敲除小鼠模型显示胚胎发育异常，提示其在细胞能量代谢中的关键作用。
2. **文献名称**：*Characterization of C19orf57 interaction with the ciliary transport machinery*
**作者**：Garcia R, Tanaka M, et al.
**摘要**：利用C19orf57特异性抗体进行免疫共沉淀和免疫组化分析，揭示了C19orf57与纤毛内运输蛋白IFT20的相互作用，表明其在纤毛形成和信号传导中的功能缺失可能导致先天性肾病。
3. **文献名称**：*C19orf57 expression correlates with glioma progression and patient survival*
**作者**：Chen L, Wang H, et al.
**摘要**：通过C19orf57抗体对胶质瘤组织进行免疫染色，发现其高表达与肿瘤恶性程度和患者不良预后显著相关，体外实验证实C19orf57通过调控细胞周期蛋白促进癌细胞增殖。
如需真实文献，建议通过PubMed或Google Scholar以“C19orf57 antibody”为关键词检索近期论文。
The C19orf57 antibody is a valuable tool for studying the function and expression of the C19orf57 protein, encoded by the *C19orf57* gene located on human chromosome 19. This gene, also known as *FLJ22555* or *CIAO3*, encodes a conserved protein implicated in mitochondrial iron-sulfur (Fe-S) cluster assembly and ribosome biogenesis. Mutations in *C19orf57* are associated with genetic disorders such as combined oxidative phosphorylation deficiency (COXPD34), a severe mitochondrial disorder characterized by metabolic acidosis, encephalopathy, and early lethality. The C19orf57 protein interacts with components of the cytosolic iron-sulfur assembly (CIA) machinery, playing a role in cellular iron homeostasis and genome stability.
C19orf57 antibodies are widely used in research applications like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization (primarily mitochondrial), and tissue distribution. These antibodies are typically generated using recombinant protein fragments or synthetic peptides as immunogens, with validation in knockout models to confirm specificity. Studies utilizing C19orf57 antibodies have advanced understanding of its involvement in mitochondrial dysfunction, metabolic diseases, and cancer, where altered expression may correlate with tumor progression. Commercial availability from multiple biotech vendors facilitates its use in both basic research and clinical investigations, aiding in biomarker discovery and mechanistic studies of Fe-S cluster-related pathologies.
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