Rabbit Polyclonal PTH1R Antibody

The parathyroid hormone 1 receptor (PTH1R) is a G protein-coupled receptor (GPCR) critical for regulating calcium and phosphate homeostasis. It binds parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP), mediating their effects on bone remodeling, kidney function, and mineral ion balance. PTH1R antibodies are autoantibodies that target this receptor, often implicated in autoimmune disorders. In rare cases, these antibodies disrupt PTH1R signaling, leading to pathological conditions. For instance, they are associated with hypoparathyroidism or pseudohypoparathyroidism, where impaired receptor activity causes hypocalcemia and hyperphosphatemia. Research also suggests a potential role of PTH1R antibodies in autoimmune thyroid diseases or rheumatologic disorders, though mechanisms remain unclear. Clinically, detecting PTH1R antibodies aids in diagnosing autoimmune-mediated calcium dysregulation. Experimental studies utilize these antibodies to explore receptor function and develop therapeutic strategies, such as antibody-neutralizing agents or receptor modulators. However, standardized assays for PTH1R antibody detection are limited, highlighting the need for further validation. Understanding their pathogenic role could advance treatments for metabolic bone diseases and autoimmune disorders linked to PTH1R dysfunction.