| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | dJ20N2.5 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FUCA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FUCA2抗体的示例参考文献(注：以下信息为示例，实际文献需通过学术数据库核实)：
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1. **文献名称**：*"FUCA2 as a novel biomarker for hepatocellular carcinoma: Diagnostic and prognostic implications"*
**作者**：Li X, et al.
**摘要**：本研究通过免疫组化分析发现，FUCA2在肝癌组织中高表达，并与患者预后不良相关。使用抗FUCA2抗体证实其可作为肝癌早期诊断和预后评估的潜在标志物。
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2. **文献名称**：*"The role of FUCA2 in regulating glycosphingolipid metabolism in colorectal cancer"*
**作者**：Wang Y, et al.
**摘要**：通过抗FUCA2抗体介导的蛋白质功能抑制实验，揭示FUCA2通过调控鞘糖脂代谢影响结直肠癌细胞的迁移和侵袭能力。
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3. **文献名称**：*"Serum FUCA2 levels detected by ELISA correlate with tumor progression in pancreatic cancer"*
**作者**：Tanaka K, et al.
**摘要**：开发基于抗FUCA2抗体的ELISA检测方法，发现胰腺癌患者血清中FUCA2水平显著升高，且与肿瘤分期及转移风险相关。
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4. **文献名称**：*"FUCA2 antibody-based immunohistochemical analysis in inflammatory bowel disease"*
**作者**：Smith J, et al.
**摘要**：利用抗FUCA2抗体进行组织染色，发现FUCA2在炎症性肠病患者的肠黏膜中表达异常，提示其参与炎症相关糖蛋白代谢紊乱。
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建议通过PubMed、Web of Science或Google Scholar以“FUCA2 antibody”或“FUCA2 biomarker”为关键词检索最新文献。
The FUCA2 antibody targets the alpha-L-fucosidase 2 (FUCA2) enzyme, a glycosidase involved in hydrolyzing α-1.6-linked fucose residues from glycoproteins and glycolipids. Unlike its isoform FUCA1. which is lysosomal, FUCA2 is secreted and functions extracellularly, potentially modulating cell-matrix interactions and signaling pathways. FUCA2 is expressed in various tissues, including the liver, kidneys, and reproductive organs, and has been implicated in physiological processes such as fertilization, inflammation, and cancer progression.
Research on FUCA2 antibodies has grown due to their utility in studying FUCA2's role in disease. For instance, reduced FUCA2 expression has been associated with tumor metastasis in certain cancers, suggesting its potential as a biomarker or therapeutic target. Antibodies against FUCA2 enable detection of its expression levels and localization in tissues or biological fluids, aiding in mechanistic studies. Additionally, FUCA2 dysregulation has been linked to neurological disorders and fucosidosis-like symptoms, though its exact pathological contributions remain under investigation. The development of specific, high-affinity FUCA2 antibodies continues to support functional analyses, including ELISA, immunohistochemistry, and Western blotting, advancing understanding of its biological and clinical significance.
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