| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ANF1A2; HELIOS; ZNF1A2; ZNFN1A2 |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IKZF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于IKZF2抗体的3篇代表性文献及其核心内容概括(注：文献信息为模拟示例，实际引用需核实)：
1. **"IKZF2 regulates immune tolerance in Treg cells via transcriptional repression of CD40L"**
- **作者**: Smith A et al.
- **摘要**: 研究利用IKZF2特异性抗体揭示IKZF2在调节性T细胞(Treg)中的功能，发现IKZF2通过抑制CD40L表达维持免疫耐受，抗体阻断实验表明其缺失导致自身免疫反应加剧。
2. **"Targeting IKZF2 in T-cell malignancies: A therapeutic antibody approach"**
- **作者**: Chen L et al.
- **摘要**: 开发了一种靶向IKZF2的人源化单克隆抗体，在T细胞白血病模型中显示抗肿瘤活性，抗体通过诱导IKZF2蛋白降解并抑制下游STAT信号通路发挥作用。
3. **"IKZF2 as a biomarker for autoimmune disease progression"**
- **作者**: Rodriguez M et al.
- **摘要**: 通过IKZF2抗体检测患者血清中IKZF2自身抗体水平，发现其与系统性红斑狼疮(SLE)疾病活动度正相关，提示IKZF2可能成为自身免疫病的诊断标志物。
**注意事项**：以上文献为领域典型研究方向模拟，实际研究中建议通过PubMed或Google Scholar以“IKZF2 antibody”或“IKZF2 function”为关键词检索最新论文，并关注高影响力期刊(如Nature Immunology, Blood等)。
The IKZF2 antibody targets the IKAROS family zinc finger 2 (IKZF2) protein, a transcription factor encoded by the *IKZF2* gene. Also known as Helios, IKZF2 belongs to the IKAROS family of proteins (IKZF1-5), which regulate hematopoietic development, immune cell differentiation, and lymphocyte function. Structurally, IKZF2 contains zinc finger domains that mediate DNA binding and protein-protein interactions, enabling its role in chromatin remodeling and transcriptional regulation.
Primarily expressed in regulatory T cells (Tregs), IKZF2 is implicated in maintaining immune tolerance by stabilizing Treg suppressive functions and preventing autoimmunity. It also influences T cell activation and differentiation in both physiological and pathological contexts. Dysregulation of IKZF2 has been associated with autoimmune disorders, immunodeficiency, and cancers, particularly hematological malignancies like leukemia and lymphoma. For instance, aberrant IKZF2 expression may contribute to tumor immune evasion or therapy resistance.
IKZF2-specific antibodies are vital tools for studying protein expression, localization, and function in research settings. They are widely used in techniques such as Western blotting, flow cytometry, and immunohistochemistry to explore IKZF2’s role in immune regulation, cancer biology, and therapeutic targeting. Recent studies also investigate IKZF2 as a biomarker or therapeutic target in CAR-T cell therapies and immune checkpoint modulation. Despite progress, its tissue-specific roles and interaction networks remain areas of active investigation, underscoring the importance of IKZF2 antibodies in advancing translational immunology and oncology research.
×
