| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NVL2 |
| WB Predicted band size | 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human NVL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NVL抗体的3篇参考文献及其摘要的概括，基于相关领域的研究方向整理而成：
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1. **文献名称**：*NVL interacts with RUVBL1/2 to regulate ribosomal RNA synthesis through RNA polymerase II*
**作者**：Takahashi H, et al.
**摘要**：本研究揭示了NVL蛋白通过与RUVBL1/2复合物相互作用，在核糖体RNA合成中调控RNA聚合酶II活性的机制。研究利用特异性NVL抗体进行染色质免疫沉淀(ChIP)，证实NVL在核仁中的功能缺失会导致rRNA前体加工异常，提示其在核糖体生物发生中的关键作用。
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2. **文献名称**：*Development of a high-affinity monoclonal antibody against human NVL for diagnostic applications in ovarian cancer*
**作者**：Chen L, et al.
**摘要**：团队开发了一种针对人源NVL蛋白的单克隆抗体，验证了其在ELISA和免疫组化中的高特异性和敏感性。通过分析卵巢癌组织样本，发现NVL表达水平与肿瘤分期呈正相关，表明其作为潜在生物标志物的临床价值。
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3. **文献名称**：*NVL-mediated proteostasis in neurodegeneration: Insights from antibody-based imaging in mouse models*
**作者**：Park S, et al.
**摘要**：研究利用新型NVL抗体对阿尔茨海默病小鼠模型的脑组织进行成像分析，发现NVL在神经元中的表达随疾病进展显著下降，并与异常蛋白聚集(如β-淀粉样蛋白)相关，提示NVL可能通过维持核蛋白稳态参与神经退行性病理过程。
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**备注**：上述文献为模拟示例，实际研究中请通过学术数据库(如PubMed、Web of Science)以“NVL antibody”“NVL protein function”等关键词检索最新成果。若需具体文献，建议补充NVL的全称或研究背景以便精准查询。
**Background of NVL Antibody**
NVL (Nuclear Valosin-containing Protein-Like) antibodies target a protein associated with ribosomal RNA (rRNA) processing and nucleolar functions. The NVL gene encodes an ATP-dependent RNA helicase belonging to the AAA+ (ATPases Associated with diverse cellular Activities) superfamily, which plays a critical role in ribosome biogenesis. NVL is involved in the maturation of the 60S ribosomal subunit by facilitating rRNA processing and structural remodeling during ribosome assembly. Its activity is essential for maintaining nucleolar integrity and cellular proliferation.
Research on NVL antibodies has gained traction due to their utility in studying ribosome biosynthesis defects linked to genetic disorders and cancers. Dysregulation of NVL expression has been implicated in conditions such as Diamond-Blackfan anemia and certain malignancies, where aberrant ribosome biogenesis drives pathological processes. NVL antibodies are employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate NVL localization, expression levels, and interactions within nucleolar complexes.
Recent studies also explore NVL's potential role in cellular stress responses and its interaction with tumor suppressors like p53. suggesting broader implications in cancer biology. These antibodies serve as vital tools for elucidating molecular mechanisms underlying ribosomopathies and developing targeted therapies for related diseases.
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