Rabbit Polyclonal PPP2R1B Antibody

The PPP2R1B antibody targets the protein encoded by the PPP2R1B gene, which is a regulatory subunit (B55β) of the serine/threonine phosphatase PP2A. PP2A is a critical enzyme involved in diverse cellular processes, including cell cycle regulation, signal transduction, and apoptosis, by counteracting kinase activities through dephosphorylation. The PPP2R1B subunit plays a key role in substrate recognition and PP2A complex assembly, modulating its activity toward specific targets like Akt, β-catenin, and Tau. Dysregulation of PPP2R1B has been implicated in cancer, neurodegenerative diseases, and other pathologies. For instance, PPP2R1B deletions or mutations are observed in colorectal, lung, and ovarian cancers, often correlating with tumor progression and poor prognosis. In Alzheimer’s disease, altered PP2A activity linked to PPP2R1B may contribute to Tau hyperphosphorylation. Antibodies against PPP2R1B are essential tools for studying PP2A complex dynamics, protein expression patterns, and post-translational modifications. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore PPP2R1B's role in cellular homeostasis and disease mechanisms. Such research aids in identifying therapeutic targets for conditions associated with PP2A dysfunction.