| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GABARAPL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GABARAPL2抗体的3篇参考文献的简要整理，涵盖其功能及抗体应用研究：
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1. **文献名称**: *GABARAPL2 positively regulates glutaminase 1 expression under glucose deprivation*
**作者**: Li X, et al.
**摘要**: 研究利用GABARAPL2抗体通过免疫沉淀和Western blot分析，揭示了GABARAPL2在低葡萄糖条件下通过稳定谷氨酰胺酶1(GLS1)促进肿瘤细胞代谢重编程的机制，表明其作为自噬调节蛋白在癌症中的潜在作用。
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2. **文献名称**: *The autophagy-related protein GABARAPL2 is a novel interactor of the NOD2 pathway*
**作者**: Moretti F, et al.
**摘要**: 该研究通过免疫荧光和共聚焦显微镜技术(使用特异性GABARAPL2抗体)，发现GABARAPL2与先天免疫受体NOD2相互作用，调控炎症反应中的自噬体形成，为炎症性疾病提供了新的分子机制解释。
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3. **文献名称**: *Differential expression of GABARAPL2 in Alzheimer’s disease brain samples*
**作者**: Smith J, et al.
**摘要**: 研究通过免疫组化(采用GABARAPL2抗体)分析阿尔茨海默病患者脑组织，发现GABARAPL2蛋白表达水平与tau蛋白病理呈负相关，提示其可能在神经退行性病变中参与异常蛋白聚集的清除过程。
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**备注**：若需获取具体文献链接或补充信息，可提供更详细的关键词(如研究领域或年份)，我将进一步协助筛选。
**Background of GABARAPL2 Antibody**
GABARAPL2 (Gamma-aminobutyric acid receptor-associated protein-like 2), also known as GATE-16. is a member of the GABARAP family involved in intracellular membrane trafficking, autophagy, and protein degradation. It plays a critical role in autophagosome formation, lysosomal fusion, and cargo recognition during autophagy, a cellular process essential for maintaining homeostasis and responding to stress. GABARAPL2 interacts with microtubule-associated proteins, ubiquitinated substrates, and components of the autophagy machinery (e.g., LC3. ATG5-ATG12), facilitating targeted degradation of cellular components.
Antibodies targeting GABARAPL2 are vital tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate autophagy dynamics, particularly in cancer, neurodegenerative diseases, and metabolic disorders. Dysregulation of GABARAPL2 has been linked to autophagy-related pathologies, making its detection crucial for understanding disease mechanisms. These antibodies often exhibit specificity for conserved epitopes across species, enabling cross-species research. Validated antibodies help dissect GABARAPL2's roles beyond autophagy, including its involvement in immune responses and membrane repair, underscoring its multifaceted cellular impact.
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