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Rabbit Polyclonal CCDC134 Antibody

  • 中文名: CCDC134抗体
  • 别    名: nan
货号: IPDX10316
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

WB Predicted band size27 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CCDC134
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CCDC134抗体的模拟参考文献示例(注:实际文献可能需要根据具体研究领域查询,以下内容为虚构示例,供参考):

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1. **文献名称**:CCDC134 as a Novel Immune Modulator: Development of a Polyclonal Antibody for Functional Studies

**作者**:Li, X. et al.

**摘要**:本研究开发了一种针对CCDC134蛋白的多克隆抗体,验证了其在人外周血单核细胞中的特异性结合能力,并发现CCDC134可能通过调节T细胞信号通路影响免疫应答。抗体成功应用于Western blot和免疫荧光实验。

2. **文献名称**:Therapeutic Potential of Anti-CCDC134 Antibody in Suppressing Tumor Growth

**作者**:Wang, Y. et al.

**摘要**:通过构建抗CCDC134的单克隆抗体,研究发现其能显著抑制小鼠模型中黑色素瘤的生长。机制研究表明,CCDC134抗体通过阻断肿瘤微环境中的免疫抑制信号发挥作用。

3. **文献名称**:CCDC134 Interaction with Cytokine Receptors: Insights from Antibody-Based Blockade Experiments

**作者**:Zhang, R. et al.

**摘要**:利用抗CCDC134抗体阻断实验,揭示了CCDC134与IL-6受体的直接相互作用,提示其在慢性炎症性疾病中的潜在调控作用。抗体被用于流式细胞术和共沉淀分析。

4. **文献名称**:A High-Affinity Anti-CCDC134 Antibody for Diagnostic Applications in Autoimmune Diseases

**作者**:Chen, H. et al.

**摘要**:开发了一种高亲和力抗CCDC134抗体,用于检测类风湿性关节炎患者血清中的CCDC134水平。临床样本分析显示,CCDC134表达与疾病活动度呈正相关。

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**注意**:以上文献为模拟内容,实际研究中请通过PubMed、Web of Science等平台检索真实发表的论文。如需具体文献支持,建议补充CCDC134相关研究背景或关键词。

背景信息

The CCDC134 (coiled-coil domain-containing protein 134) antibody is a research tool developed to study the function and expression of the CCDC134 protein, a member of the coiled-coil domain-containing protein family. CCDC134 is implicated in regulating immune responses and cellular signaling pathways. Early studies suggest it acts as a cytokine-like factor, influencing T-cell activation and differentiation, and may play roles in autoimmune diseases and cancer progression. Its involvement in modulating the MAPK/ERK signaling pathway highlights its potential impact on cell proliferation and apoptosis. The antibody, typically generated in hosts like rabbits or mice using immunogenic peptide fragments or recombinant proteins, enables detection of CCDC134 in techniques such as Western blotting, immunohistochemistry, and flow cytometry. Validation often includes testing in cell lines or tissues with confirmed CCDC134 expression and assessing cross-reactivity. Researchers utilize this antibody to explore CCDC134's role in tumor microenvironments, immune evasion mechanisms, and therapeutic targeting. Its development addresses the need for reliable tools to decipher CCDC134's biological significance, offering insights into its diagnostic or therapeutic potential in diseases like hepatocellular carcinoma and rheumatoid arthritis.

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