| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GLAT; IBD1; BLOCK25; HEL-S-63p |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GALM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GALM抗体的3篇示例文献(内容为假设性示例，仅供参考)：
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1. **文献名称**：*"Development of a Novel Monoclonal Antibody Targeting GALM for Immunohistochemical Analysis in Colorectal Cancer"*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种高特异性抗GALM单克隆抗体，并验证了其在结直肠癌组织中的免疫组化应用。结果显示，GALM蛋白在肿瘤微环境中过表达，且与患者生存率降低显著相关。
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2. **文献名称**：*"GALM Expression in Metabolic Disorders: A Comparative Study Using Polyclonal Antibody-Based ELISA"*
**作者**：Lee H, et al.
**摘要**：通过基于多克隆抗体的ELISA技术，作者分析了代谢综合征患者血清中GALM的水平，发现GALM与胰岛素抵抗呈正相关，提示其可能作为代谢紊乱的潜在生物标志物。
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3. **文献名称**：*"Role of GALM in Neuronal Development: Insights from Antibody-Mediated Knockdown in Mouse Models"*
**作者**：Garcia R, et al.
**摘要**：研究利用抗GALM抗体进行功能阻断实验，揭示了GALM在小鼠海马神经元突触形成中的关键作用，为神经发育障碍的机制提供了新视角。
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**备注**：以上文献为虚构示例，实际研究中请通过PubMed、Google Scholar等平台检索真实文献。若需具体文献支持，可补充GALM相关研究背景(如疾病领域或抗体类型)。
The GALM (galactose mutarotase) antibody is a research tool designed to detect and quantify the GALM enzyme, which plays a critical role in galactose metabolism. GALM catalyzes the conversion of β-D-galactose to α-D-galactose, a necessary step for galactose utilization via the Leloir pathway. Deficiencies or dysregulation of GALM are linked to metabolic disorders, including type 2 diabetes and rare forms of galactosemia, though its clinical significance is less well-characterized compared to other enzymes in the pathway (e.g., GALT).
GALM antibodies are typically produced in immunized hosts (e.g., rabbits, mice) using purified recombinant GALM protein or peptide fragments as antigens. These antibodies enable the study of GALM expression, localization, and function in tissues and cell lines through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies have explored GALM's potential role in cancer progression and neurodegenerative diseases, driving demand for reliable antibodies to validate findings. Commercial GALM antibodies are often validated for specificity using knockout controls or siRNA-mediated silencing. However, researchers must verify cross-reactivity and batch consistency, as non-specific binding has been reported. Overall, GALM antibodies remain vital for elucidating the enzyme's biological and pathological mechanisms.
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