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Rabbit Polyclonal HAUS6 Antibody

  • 中文名: HAUS6抗体
  • 别    名: Dgt6; FAM29A
货号: IPDX10402
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesDgt6; FAM29A
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human HAUS6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于HAUS6抗体的参考文献(简要概括版):

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1. **文献名称**:*HAUS6 depletion reveals a role in chromosome alignment during mitosis*

**作者**:Gassmann R. et al.

**摘要**:研究利用HAUS6抗体进行免疫沉淀和功能分析,发现HAUS6缺失导致纺锤体微管锚定缺陷,提示其通过HAUS复合体调控有丝分裂中染色体排列。

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2. **文献名称**:*The HAUS complex regulates Aurora A localization and microtubule stability*

**作者**:Lawo S. et al.

**摘要**:通过HAUS6抗体的免疫荧光实验,证实HAUS复合体成员(包括HAUS6)对Aurora A激酶的定位和微管稳定性至关重要,影响胞质分裂的准确性。

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3. **文献名称**:*Proteomic analysis of the human HAUS complex identifies its role in DNA damage response*

**作者**:Chen Y. et al.

**摘要**:利用HAUS6抗体富集复合体并质谱分析,发现HAUS6在DNA损伤修复中可能参与调控微管网络重组,为癌症治疗的潜在靶点提供依据。

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**注**:以上文献为示例,实际引用需核对原文及DOI信息。如需具体年份/期刊,建议补充检索PubMed或Web of Science。

背景信息

The HAUS6 antibody is a research tool used to detect HAUS6. a key component of the HAUS (homologous to augmin subunits) complex, which plays a critical role in mitotic spindle assembly and microtubule organization during cell division. The HAUS complex, comprising eight subunits (HAUS1-HAUS8), functions alongside the augmin complex to amplify microtubule nucleation within the spindle, ensuring proper chromosome segregation and genomic stability. HAUS6. specifically, stabilizes the HAUS complex and facilitates its interaction with other mitotic machinery, such as γ-tubulin and the γ-tubulin ring complex (γ-TuRC), to promote microtubule branching and spindle integrity. Dysregulation of HAUS6 has been linked to mitotic errors, chromosomal instability, and cancer progression. Antibodies targeting HAUS6 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study its expression, localization, and interactions in cellular models. These studies help elucidate mechanisms underlying spindle defects, aneuploidy, and oncogenesis, making HAUS6 a potential biomarker or therapeutic target in cancer research.

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