| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ANT2BP; TANGO9; C2orf18 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SLC35F6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SLC35F6抗体相关的研究文献示例(注：文献信息为模拟虚构，供参考)：
1. **"SLC35F6 as a prognostic biomarker in hepatocellular carcinoma: Immunohistochemical analysis"**
*Zhang et al., 2021*
摘要：通过开发并验证SLC35F6特异性多克隆抗体，研究发现肝癌组织中SLC35F6蛋白高表达与患者生存率降低显著相关，提示其作为预后标志物的潜力。
2. **"Functional characterization of SLC35F6 in lung cancer using CRISPR/Cas9 and antibody-based assays"**
*Wang et al., 2019*
摘要：利用CRISPR/Cas9敲低SLC35F6基因，结合抗体验证发现，SLC35F6缺失抑制肺癌细胞增殖和迁移，其抗体被用于Western blot和免疫荧光定位细胞膜表达。
3. **"SLC35F6-mediated nucleotide sugar transport: Structural insights from cryo-EM and antibody mapping"**
*Li et al., 2020*
摘要：通过冷冻电镜解析SLC35F6蛋白结构，结合单克隆抗体表位定位实验，揭示了该转运蛋白在核苷酸糖跨膜运输中的关键结构域及功能机制。
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**备注**：实际文献需通过PubMed、Google Scholar等平台检索确认。若需真实文献，建议使用关键词“SLC35F6 antibody”或“SLC35F6 function”查询近年发表的文章。
The SLC35F6 antibody is a research tool designed to detect the solute carrier family 35 member F6 (SLC35F6), a protein belonging to the SLC35 family of nucleotide-sugar transporters. These transporters are primarily localized in the Golgi apparatus and endoplasmic reticulum, facilitating the translocation of nucleotide sugars required for glycosylation processes. SLC35F6 is implicated in cellular glycosylation homeostasis, though its exact substrates and physiological roles remain under investigation. Recent studies suggest its potential involvement in cancer biology, with altered expression observed in certain tumors, possibly influencing cell proliferation, metastasis, or drug resistance.
The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study SLC35F6 expression patterns across tissues or cell lines. Commercial SLC35F6 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein’s conserved regions. Validation often includes knockout cell lines or siRNA-mediated silencing to confirm specificity. Challenges in its application may arise from cross-reactivity with other SLC family members due to structural homology.
Research utilizing this antibody contributes to elucidating SLC35F6’s role in cellular metabolism, disease mechanisms, and its potential as a biomarker or therapeutic target. However, comprehensive functional studies are still needed to fully define its biological significance.
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