| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FINCA |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human NHLRC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NHLRC2抗体的3篇假想文献示例(注：实际文献需通过学术数据库验证)：
1. **文献名称**：*NHLRC2 Antibody Characterization in Cancer Cell Lines*
**作者**：Smith, A.B. et al.
**摘要**：研究利用NHLRC2抗体分析其在多种癌细胞中的表达水平，发现NHLRC2在卵巢癌中高表达，并与肿瘤增殖相关，提示其作为潜在生物标志物的可能性。
2. **文献名称**：*Structural Insights into NHLRC2-Protein Interactions via Immunoprecipitation*
**作者**：Chen, L. & Tanaka, M.
**摘要**：通过NHLRC2抗体进行免疫共沉淀实验，揭示NHLRC2与泛素连接酶复合物的相互作用，阐明其在蛋白质降解通路中的调控机制。
3. **文献名称**：*NHLRC2 Antibody Application in Neurodegenerative Disease Models*
**作者**：Gupta, R. et al.
**摘要**：在小鼠模型中，NHLRC2抗体检测到该蛋白在神经元中的异常聚集，表明NHLRC2可能参与tau蛋白病理过程，与阿尔茨海默病相关。
(提示：以上为模拟内容，实际研究中请通过PubMed、Web of Science等平台检索具体文献。)
The NHLRC2 antibody targets the NHLRC2 protein, encoded by the *NHLRC2* gene, which belongs to the NHL repeat-containing protein family. NHLRC2 is hypothesized to function as an E3 ubiquitin ligase, playing a role in protein ubiquitination and degradation via the ubiquitin-proteasome system. While its exact biological mechanisms remain under investigation, NHLRC2 is linked to cellular processes such as protein quality control, stress response, and possibly tumor suppression.
Interest in NHLRC2 antibodies stems from their utility in studying NHLRC2's expression, localization, and interactions in diseases. Mutations in *NHLRC2* are associated with FINCA syndrome (Fibrosis, Neurodegeneration, and Cerebral Angiomatosis), a rare autosomal recessive disorder, making these antibodies critical for diagnostic and functional studies. Researchers employ NHLRC2 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its tissue distribution and dysregulation in pathological contexts, including cancer and neurodegenerative conditions.
Despite progress, many aspects of NHLRC2’s role remain unclear. Current studies focus on its involvement in ER-associated degradation (ERAD) and crosstalk with autophagy pathways. NHLRC2 antibodies also aid in validating experimental models, such as CRISPR-edited cell lines or animal models, to dissect disease mechanisms. Overall, NHLRC2 antibodies serve as essential tools for unraveling the protein’s contribution to cellular homeostasis and disease, with potential implications for therapeutic targeting.
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