| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KS; CEM1; KASI; FASN2D |
| WB Predicted band size | 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human OXSM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于假设的示例性参考文献，供参考(请注意，OXSM相关文献可能较少，建议通过学术数据库进一步核实)：
1. **标题**：Mitochondrial OXSM regulates ketone body metabolism in neuronal cells
**作者**：Lee et al., 2018
**摘要**：研究OXSM在线粒体酮体代谢中的作用，通过特异性抗体验证其在神经元中的表达，发现OXSM缺失导致乙酰乙酸代谢异常，影响脑能量稳态。
2. **标题**：OXSM antibody-based profiling in hepatocellular carcinoma
**作者**：Zhang et al., 2020
**摘要**：利用OXSM抗体分析肝癌组织样本，发现OXSM表达水平与肿瘤进展相关，提示其可能作为代谢重编程的生物标志物。
3. **标题**：Role of OXSM in mitochondrial oxidative stress response
**作者**：Garcia-Ruiz et al., 2016
**摘要**：通过免疫印迹和免疫荧光技术，证实OXSM在氧化应激条件下调控线粒体酶活性，影响细胞凋亡通路。
4. **标题**：OXSM knockout mice exhibit impaired fatty acid oxidation
**作者**：Smith et al., 2019
**摘要**：开发OXSM基因敲除模型，结合抗体检测组织分布，证明OXSM缺失导致脂肪酸氧化障碍及肌肉代谢紊乱。
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**提示**：
- 上述文献为模拟示例，实际研究中建议通过PubMed、Google Scholar等平台以“OXSM antibody”或“OXSM protein function”为关键词检索最新文献。
- 若OXSM为特定研究领域术语，需结合上下文确认其全称(如Oxidative Stress Modifier或特定酶类)。
OXSM (Oxysterol-binding protein-related protein 7. ORP7) is a member of the OSBP-related protein family, which is involved in lipid metabolism, intracellular membrane trafficking, and cell signaling. These proteins typically contain a conserved oxysterol-binding domain (OSBP-related domain, ORD) that binds oxysterols, cholesterol, or phospholipids, enabling their role as lipid sensors or transporters. OXSM is particularly associated with regulating lipid distribution between cellular membranes, such as the endoplasmic reticulum (ER) and Golgi apparatus, and may influence membrane contact site dynamics. Dysregulation of OXSM has been implicated in metabolic disorders, neurodegenerative diseases, and cancers due to its impact on lipid homeostasis and signaling pathways.
OXSM antibodies are essential tools for detecting and quantifying OXSM protein expression in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study OXSM localization, interaction partners, and expression patterns in various tissues or disease models. Such studies help elucidate OXSM’s role in lipid-mediated processes, including apoptosis, autophagy, and vesicular transport. Additionally, OXSM antibodies contribute to exploring its potential as a biomarker or therapeutic target in conditions linked to lipid dysregulation, such as atherosclerosis or liver disease.
Overall, OXSM antibodies advance our understanding of lipid-centric cellular mechanisms and their pathological implications.
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