| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RNF93; ZNFB7; ZNF178 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TRIM15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TRIM15抗体的3篇参考文献示例(文献信息为模拟概括，实际引用需核实)：
---
1. **文献名称**: *TRIM15 modulates antiviral immunity through ubiquitination of MAVS*
**作者**: Li X, et al.
**摘要**: 本研究利用TRIM15特异性抗体，通过免疫共沉淀和Western blot技术，揭示了TRIM15通过泛素化修饰线粒体抗病毒信号蛋白(MAVS)调控Ⅰ型干扰素通路的机制，为抗病毒免疫提供了新靶点。
---
2. **文献名称**: *Characterization of TRIM15 as a regulator of NLRP3 inflammasome activation*
**作者**: Zhang Y, et al.
**摘要**: 作者通过TRIM15抗体检测其在巨噬细胞中的表达，发现TRIM15通过靶向NLRP3炎性小体进行降解，从而抑制IL-1β的分泌，提示其在炎症性疾病中的潜在治疗作用。
---
3. **文献名称**: *Development and validation of a polyclonal antibody against human TRIM15 for immunohistochemical analysis*
**作者**: Wang H, et al.
**摘要**: 该文献报道了一种针对人源TRIM15的多克隆抗体的制备与验证，通过免疫组化和流式细胞术证明其特异性，并用于多种癌症组织中TRIM15表达水平的检测。
---
如需实际文献，建议在PubMed或Google Scholar中检索关键词“TRIM15 antibody”或结合具体研究背景筛选近期论文。
TRIM15 (Tripartite Motif-containing protein 15) is a member of the TRIM family, a group of proteins characterized by conserved RING, B-box, and coiled-coil domains. These proteins are involved in diverse cellular processes, including innate immunity, antiviral defense, and autophagy. TRIM15. specifically, has been implicated in regulating immune signaling pathways and viral restriction. Studies suggest it acts as an E3 ubiquitin ligase, mediating protein ubiquitination to influence processes like NF-κB and MAPK signaling. It also exhibits antiviral activity against certain viruses, including HIV-1. by targeting viral capsids or interfering with viral replication cycles.
TRIM15 antibodies are essential tools for studying the protein's expression, localization, and functional roles. They enable detection of TRIM15 in various experimental setups, such as Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are particularly valuable in research exploring innate immune responses, host-pathogen interactions, and TRIM15's potential involvement in diseases like autoimmune disorders or cancers. Validation of TRIM15 antibodies typically includes testing for specificity using knockout cell lines or siRNA-mediated knockdown to ensure minimal cross-reactivity with other TRIM family members. Recent studies also highlight its role in regulating inflammasome activation and cytokine production, further emphasizing its relevance in inflammatory and infectious disease contexts.
×
