| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TFQTL1 |
| WB Predicted band size | 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TF |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TF(组织因子)抗体的代表性文献摘要信息：
1. **文献名称**：Antibody-mediated targeting of tissue factor: A novel anticancer therapy
**作者**：Huang X., et al.
**摘要**：该研究开发了一种靶向组织因子(TF)的单克隆抗体，通过抑制TF介导的肿瘤细胞信号通路和血管生成，显著抑制了多种实体瘤的生长，为癌症靶向治疗提供了新策略。
2. **文献名称**：Role of anti-tissue factor antibodies in experimental sepsis
**作者**：Pawlinski R., et al.
**摘要**：研究证明抗TF抗体可通过阻断TF-凝血因子VIIa复合物形成，减少内毒素诱导的弥散性血管内凝血(DIC)和器官损伤，提示其在脓毒症治疗中的潜在应用价值。
3. **文献名称**：Autoantibodies against tissue factor pathway inhibitor in antiphospholipid syndrome
**作者**：Atsumi T., et al.
**摘要**：首次报道抗磷脂综合征患者体内存在抗TF通路抑制物(TFPI)的自身抗体，此类抗体通过干扰TF相关凝血调节机制，可能参与疾病血栓形成病理过程。
(注：以上为模拟文献摘要，实际引用时建议通过PubMed/Web of Science等平台检索最新高质量研究)
Thyroid antibodies (TF antibodies), particularly thyroglobulin antibodies (TgAbs) and thyroid peroxidase antibodies (TPOAbs), are autoantibodies targeting thyroid-specific proteins. They play a central role in autoimmune thyroid diseases (AITDs) such as Hashimoto's thyroiditis and Graves' disease. In these conditions, the immune system mistakenly attacks thyroid tissue, leading to inflammation, dysfunction, or structural damage. TgAbs target thyroglobulin, a precursor protein essential for thyroid hormone synthesis, while TPOAbs inhibit thyroid peroxidase, an enzyme critical in hormone production. Elevated levels of these antibodies are diagnostic biomarkers for AITDs and correlate with disease progression.
Though their exact triggers remain unclear, genetic predisposition, environmental factors (e.g., iodine intake, infections), and immune dysregulation are implicated. TF antibodies are detected via immunoassays and aid in differentiating autoimmune thyroid disorders from non-autoimmune causes (e.g., iodine deficiency). Notably, their presence in euthyroid individuals may predict future thyroid dysfunction. Recent studies also explore their role in fertility issues, pregnancy outcomes, and extra-thyroidal autoimmune conditions. While not directly pathogenic, TF antibodies serve as key indicators of autoimmune activity, guiding clinical management and monitoring. Research continues to investigate their molecular mechanisms and therapeutic targets.
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