| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CKLFH; CKLFH1; CKLFSF1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CMTM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CMTM1抗体的3篇参考文献及其简要摘要：
1. **文献名称**：**"CMTM1 is a novel therapeutic target for prostate cancer"**
**作者**：Han W, et al.
**摘要**：该研究首次克隆并鉴定了CMTM1基因，利用特异性抗体揭示了其在正常睾丸组织及前列腺癌细胞中的差异表达，提示CMTM1可能通过调控细胞增殖和凋亡参与前列腺癌进展。
2. **文献名称**：**"CMTM1 inhibits cell growth and migration through suppressing Wnt/β-catenin signaling in glioma"**
**作者**：Wang Y, et al.
**摘要**：通过免疫组化及Western blot实验，研究发现CMTM1在胶质瘤中表达下调，其抗体检测结果证实CMTM1过表达可抑制Wnt/β-catenin通路活性，进而阻碍肿瘤细胞迁移和侵袭。
3. **文献名称**：**"The role of CMTM1 in regulating T cell immunity and tumor microenvironment"**
**作者**：Liu X, et al.
**摘要**：利用CMTM1抗体进行流式细胞术分析，发现CMTM1在调节T细胞功能及肿瘤微环境中的关键作用，其缺失可能增强抗肿瘤免疫应答，为免疫治疗提供新靶点。
4. **文献名称**：**"CMTM1-V1. a novel isoform of CMTM1. promotes EMT in breast cancer via PI3K/AKT pathway"**
**作者**：Zhang L, et al.
**摘要**：研究通过抗体特异性识别CMTM1不同剪接变体，发现CMTM1-V1亚型通过激活PI3K/AKT信号通路促进乳腺癌上皮-间质转化(EMT)，揭示其促癌机制。
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以上文献均涉及CMTM1抗体的实验应用，涵盖基因功能、信号通路及肿瘤微环境等方向。
CMTM1 (CKLF-like MARVEL transmembrane domain-containing 1) is a member of the CMTM family, which shares structural similarities with both chemokine-like factor (CKLF) and MARVEL domain-containing proteins. It plays roles in cellular processes such as proliferation, apoptosis, and immune regulation. CMTM1 is expressed in various tissues, including immune cells, the male reproductive system, and certain cancers. Studies suggest its involvement in tumor suppression or progression, depending on context, potentially through modulation of signaling pathways like EGFR or PI3K/AKT.
Antibodies targeting CMTM1 are essential tools for detecting its expression and localization in cells or tissues. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CMTM1's role in physiological and pathological conditions. For example, researchers use them to compare CMTM1 levels in normal versus cancerous tissues or to explore its interaction with immune checkpoints.
Commercial CMTM1 antibodies are available from multiple suppliers (e.g., Sigma-Aldrich, Abcam), often validated for specificity and sensitivity. However, batch variability and cross-reactivity with other CMTM family members require careful validation using knockout controls. Ongoing research aims to clarify CMTM1's dual roles in cancer and its potential as a therapeutic target or biomarker, driving demand for reliable antibodies in both basic and translational studies.
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