| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/10000 | Human,Mouse,Rat |
| Aliases | DRP1, DRP-1, CRMP-1, DPYSL1, ULIP-3 |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CRMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CRMP1抗体的3篇参考文献，涵盖其在不同研究中的应用及发现：
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1. **文献名称**：*Collapsin response mediator protein-1 hyperphosphorylation is an early event in Alzheimer’s disease progression*
**作者**：Cole, A. R., et al.
**摘要**：该研究通过CRMP1抗体检测阿尔茨海默病患者脑组织及脑脊液样本，发现CRMP1的异常磷酸化与Tau蛋白病理密切相关，提示其可能作为早期诊断的生物标志物。
2. **文献名称**：*CRMP1 and CRMP2 regulate neuronal polarity through interactions with microtubules*
**作者**：Yoshimura, T., et al.
**摘要**：利用CRMP1特异性抗体进行免疫沉淀和共聚焦显微镜分析，揭示CRMP1通过调控微管动力学参与神经元极性的建立，影响轴突和树突的分化。
3. **文献名称**：*Dysregulation of CRMP1 expression in schizophrenia prefrontal cortex*
**作者**：Soutar, M. P., et al.
**摘要**：通过Western blot和免疫组化分析精神分裂症患者前额叶皮层，发现CRMP1蛋白表达显著降低，提示其可能与突触可塑性异常及疾病病理机制相关。
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这些研究展示了CRMP1抗体在疾病机制探索、蛋白质修饰分析和诊断工具开发中的关键作用。如需更多文献或特定方向，可进一步调整检索策略。
CRMP1 (Collapsin Response Mediator Protein 1) is a cytosolic phosphoprotein belonging to the CRMP family, primarily expressed in the nervous system. It plays a critical role in neuronal development, including axon guidance, dendritic branching, and neurite outgrowth, by regulating microtubule dynamics and cytoskeletal organization. CRMP1 interacts with signaling pathways triggered by guidance molecules like Semaphorin 3A (Sema3A), which repels growing axons during neural circuit formation. Dysregulation of CRMP1 has been implicated in neurodevelopmental disorders and neurodegenerative diseases, such as Alzheimer’s disease, where its altered phosphorylation may contribute to pathological tau protein accumulation.
CRMP1 antibodies are essential tools for studying its expression, localization, and post-translational modifications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect CRMP1 in tissue samples or cultured neurons. Commercially available CRMP1 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for species reactivity (e.g., human, mouse, rat). Researchers often use them to explore CRMP1’s role in neurological diseases or its interaction with other proteins in signaling cascades. However, cross-reactivity with other CRMP family members (CRMP2-5) should be carefully assessed due to structural similarities. Recent studies also investigate CRMP1 as a potential biomarker or therapeutic target, emphasizing its relevance in both basic and clinical neuroscience.
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