| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SARP3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SFRP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SFRP5抗体的3篇参考文献示例(内容基于公开研究整理，非真实文献)：
1. **文献名称**：*SFRP5 Antibody Attenuates Adipose Tissue Inflammation and Insulin Resistance in Obesity*
**作者**：Hiroyuki Mori, et al.
**摘要**：研究通过SFRP5抗体抑制Wnt5a信号通路，发现其能减少脂肪组织巨噬细胞浸润，改善肥胖小鼠的胰岛素抵抗，提示SFRP5抗体在代谢疾病中的治疗潜力。
2. **文献名称**：*SFRP5 Expression in Ovarian Cancer and Its Correlation with Prognosis*
**作者**：Emily R. Parker, et al.
**摘要**：利用SFRP5抗体检测卵巢癌组织中SFRP5蛋白表达水平，发现低表达与患者预后不良相关，表明SFRP5可能作为肿瘤抑制因子及潜在的诊断标志物。
3. **文献名称**：*Development of a Monoclonal SFRP5 Antibody for Blocking Wnt Signaling in Pancreatic Cancer*
**作者**：James K. Lee, et al.
**摘要**：报道了一种高特异性SFRP5单克隆抗体的开发，该抗体通过中和Wnt5a活性抑制胰腺癌细胞侵袭和转移，为靶向治疗提供了新工具。
4. **文献名称**：*SFRP5 as a Serum Biomarker in Type 2 Diabetes: Validation via ELISA with a Novel Polyclonal Antibody*
**作者**：Maria Sánchez-Quintana, et al.
**摘要**：通过新型SFRP5多克隆抗体建立ELISA检测法，证实2型糖尿病患者血清SFRP5水平显著降低，提示其作为代谢紊乱相关生物标志物的价值。
(注：以上文献为示例，实际引用时请核实真实来源。)
**Background of SFRP5 Antibody**
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family, which acts as a soluble modulator of Wnt signaling by binding to Wnt proteins or frizzled receptors, thereby inhibiting canonical and non-canonical Wnt pathways. SFRP5 is predominantly expressed in adipose tissue and plays a role in metabolic regulation, inflammation, and cellular differentiation. Dysregulation of SFRP5 has been implicated in diseases such as obesity, type 2 diabetes, and cancer, where its tumor-suppressive function is often silenced via promoter hypermethylation.
SFRP5 antibodies are tools designed to detect, quantify, or neutralize SFRP5 protein in experimental and clinical settings. In research, these antibodies are used to study SFRP5's expression patterns, interaction with Wnt ligands, and its role in pathways linked to carcinogenesis or metabolic disorders. For instance, reduced SFRP5 levels in tumors (e.g., gastric, colorectal cancers) correlate with Wnt hyperactivation, promoting proliferation and metastasis. Therapeutic applications are emerging, with antibody-based strategies exploring SFRP5 restoration to counteract Wnt-driven pathologies. However, challenges remain in specificity and understanding context-dependent roles, as SFRP5 may exhibit dual functions in different tissues or disease stages. Validation of SFRP5 antibodies remains critical for ensuring reliability in diagnostics and functional studies.
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