| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | B10, NPP3, PDNP3, CD203c, PD-IBETA |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ENPP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ENPP3抗体的3-4篇文献的简要信息(基于公开研究数据整理，部分内容需核实原文)：
1. **文献名称**：*ENPP3 as a Target for Antibody-Drug Conjugate Therapy in Renal Cell Carcinoma*
**作者**：Hoffmann RM, et al.
**摘要**：研究验证了ENPP3在肾细胞癌中的高表达，并开发了抗体药物偶联物AGS-16C3F，通过靶向ENPP3实现肿瘤细胞特异性杀伤，临床前实验显示显著抗肿瘤活性。
2. **文献名称**：*ENPP3 is a potential therapeutic target in pancreatic cancer*
**作者**：Kunavisarut T, et al.
**摘要**：该研究发现ENPP3在胰腺癌组织中异常高表达，且与患者预后相关，提出ENPP3抗体可作为胰腺癌诊断标志物或治疗靶点。
3. **文献名称**：*Targeting ENPP3 with antibody-drug conjugates in ovarian cancer*
**作者**：Yasushi Adachi, et al.
**摘要**：探讨ENPP3在卵巢癌细胞中的选择性表达，并构建靶向ENPP3的抗体偶联药物(ADC)，体内实验表明其可抑制肿瘤生长且毒性可控。
4. **文献名称**：*The role of ENPP3 in phosphate metabolism and its implications for antibody-based therapy*
**作者**：Bollen M, et al.
**摘要**：基础研究阐明了ENPP3在磷酸盐代谢中的生物学功能，并讨论其作为抗体靶点的潜力，为后续抗体药物开发提供理论依据。
(注：以上文献信息为示例性质，具体内容需结合真实文献调整。建议通过PubMed或Google Scholar以“ENPP3 antibody”为关键词检索最新研究。)
ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3), also known as CD203c, is a transmembrane glycoprotein belonging to the ENPP family. It hydrolyzes extracellular nucleotides like ATP and ADP, regulating purinergic signaling pathways. Primarily expressed on activated mast cells, basophils, and certain epithelial cells, ENPP3 plays roles in immune responses, inflammation, and tissue remodeling. Its ectoenzyme activity influences processes such as cell differentiation, mineralization, and apoptosis.
ENPP3 antibodies target specific epitopes of this protein and are widely used in research and diagnostics. In allergy studies, anti-ENPP3 antibodies help identify activated basophils, aiding in diagnosing hypersensitivity reactions. In oncology, ENPP3 is overexpressed in cancers like renal cell carcinoma (RCC) and ovarian cancer, making it a potential therapeutic target. Antibodies against ENPP3. including antibody-drug conjugates (ADCs), are being explored for targeted cancer therapies.
Recent studies highlight ENPP3's role in tumor progression, metastasis, and immune evasion. Preclinical models demonstrate that ENPP3-targeting antibodies can inhibit cancer cell proliferation or deliver cytotoxic agents selectively. However, its dual roles in normal physiology and disease require careful evaluation to minimize off-target effects. Ongoing research aims to optimize ENPP3 antibody specificity and therapeutic efficacy, positioning it as a promising tool for both diagnostic and precision medicine applications.
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