| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | HOX1, HOX1I |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXA11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXA11抗体的3篇代表性文献的简要总结(文献信息为模拟示例，实际引用需核实原文)：
1. **"HOXA11 expression in endometrial tissues and its role in endometriosis"**
*作者：Taylor HS, et al. (2006)*
摘要：通过免疫组化分析，研究发现HOXA11抗体标记显示其在子宫内膜异位症患者的异位内膜中表达显著降低，提示HOXA11调控异常可能参与疾病发生。
2. **"HOXA11 as a prognostic biomarker in ovarian cancer"**
*作者：Cheng W, et al. (2012)*
摘要：利用HOXA11抗体进行Western blot和免疫组化检测，发现卵巢癌组织中HOXA11蛋白高表达与患者生存期缩短及化疗耐药性相关，提示其作为预后标志物的潜力。
3. **"HOXA11 regulates limb development via Wnt signaling pathway"**
*作者：Yokouchi Y, et al. (1995)*
摘要：在小鼠胚胎研究中，通过抗体介导的HOXA11蛋白定位分析，证实其在肢体近远端轴向发育中起关键作用，并调控Wnt通路基因表达。
The HOXA11 antibody is a crucial tool in studying the HOXA11 protein, encoded by the *HOXA11* gene within the HOX gene family. HOX genes are evolutionarily conserved transcription factors that regulate embryonic development, particularly body patterning and organogenesis. HOXA11 is specifically involved in limb development, urogenital system formation, and female reproductive tract differentiation. Its expression is tightly regulated during embryogenesis but may reappear in certain pathological contexts, such as cancers.
HOXA11 antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein localization, expression levels, and interactions. Research highlights its dual roles: in development, it guides uterine and limb morphogenesis, while in oncology, aberrant HOXA11 expression is linked to ovarian, endometrial, and cervical cancers. It may act as a tumor suppressor or promoter depending on the cancer type and microenvironment.
Clinically, HOXA11 dysregulation is associated with endometriosis, infertility, and congenital uterine anomalies. Antibodies against HOXA11 aid in exploring these mechanisms, offering insights into diagnostic or therapeutic strategies. However, variability in antibody specificity (due to protein isoforms or post-translational modifications) requires careful validation. Overall, HOXA11 antibodies remain vital for dissecting developmental pathways and disease mechanisms, bridging basic research and translational applications.
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