Rabbit Polyclonal JAK2 Antibody

The JAK2 (Janus kinase 2) antibody is a critical tool in studying the JAK-STAT signaling pathway, which regulates cellular processes like hematopoiesis, immune responses, and cell growth. JAK2. a tyrosine kinase, binds to cytokine receptors and activates downstream STAT proteins upon ligand binding. Dysregulation of JAK2. particularly the V617F mutation in exon 14. is linked to myeloproliferative neoplasms (MPNs) such as polycythemia vera and myelofibrosis. This gain-of-function mutation causes constitutive kinase activity, driving uncontrolled cell proliferation. Antibodies targeting JAK2 are essential for detecting this mutation via techniques like immunohistochemistry (IHC), ELISA, or Western blotting, aiding in MPN diagnosis and classification. They also help assess JAK2 expression levels in research exploring inflammatory diseases, autoimmune disorders, and cancers. Therapeutic JAK2 inhibitors (e.g., ruxolitinib) are used in MPN treatment, and JAK2 antibodies play a role in monitoring drug efficacy and resistance. Cross-reactivity with other JAK family members (JAK1. JAK3. TYK2) is a consideration in assay design. Overall, JAK2 antibodies bridge clinical diagnostics and molecular research, enhancing understanding of JAK-STAT signaling in health and disease.